Abstract
Background
The association of variants in the IL23R gene with psoriasis and psoriatic arthritis (PsA) is a robust genetic finding
Objectives
To assess whether combined evidence shows the association between IL23R polymorphisms and susceptibility to psoriasis/PsA.
Methods
We conducted a meta-analysis to examine the association between the IL23R rs11209026 (Q381R), rs7530511 (L310P), and rs2201841 polymorphisms and psoriasis/PsA.
Results
Thirteen articles met the inclusion criteria and contributed data to the meta-analysis. For rs11209026, the odds ratios (ORs) of minor alleles for psoriasis and PsA were 0.616 [95 % confidence interval (CI) 0.563–0.674] and 0.630 (95 % CI 0.524–0.757), respectively. For rs7530511, the pooled ORs were 0.820 (95 % CI 0.764–0.879) for psoriasis and 0.875 (95 % CI 0.766–1.000) for PsA; for rs2201841 the OR was 1.121 (95 % CI 1.031–1.219) for psoriasis. In genotypic analysis, the association of rs11209026 (A) and rs7530511 (T) were compatible with the dominant model (P < 0.0001, P = 0.001 respectively). The overall ORs for GG vs. AA (OR 1.339; 95 % CI 1.151–1.558), GG vs. GA (OR 1.143; 95 % CI 1.004–1.300), dominant (OR 1.226; 95 % CI 1.143–1.316), and recessive (OR 1.254; 95 % CI 1.115–1.411) models of rs2201841 were all significantly increased in psoriasis. No publication bias was present.
Conclusions
Our results demonstrate a significant association between IL23R gene polymorphisms and psoriasis/PsA.
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Acknowledgments
We thank all who have helped with this paper. We received the kind help of Dr. Yumei-Wu who gave us detailed explanations of their research.
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The authors state no conflict of interest.
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Kun-Ju Zhu and Cheng-Yao Zhu contributed equally to this work.
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Zhu, KJ., Zhu, CY., Shi, G. et al. Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis. Inflamm. Res. 61, 1149–1154 (2012). https://doi.org/10.1007/s00011-012-0509-8
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DOI: https://doi.org/10.1007/s00011-012-0509-8