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Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions

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Abstract

Objectives

Protein oxidation plays a key role in the pathogenesis of oncological diseases. In this study, we analyzed the oxidative stress in untreated multiple myeloma (MM) patients and in patients affected by monoclonal gammopathy of uncertain significance (MGUS).

Methods

We evaluated serum levels of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs), and protein nitrosylation in patients with monoclonal gammopathy and in control subjects.

Results

Serum levels of AOPPs and S-nitrosylated proteins were significantly increased in MM patients in comparison to controls and to MGUS subjects. Moreover, in MM patients the levels of AOPPs, AGEs and S-nitrosylated proteins were significantly higher in patients with bone lesions compared with those without lytic bone lesions.

Conclusions

MM is closely associated with oxidative stress and further investigation might provide an insight to understand a putative causal link between oxidative stress and MM disease onset and progression or MM complications.

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Abbreviations

MM:

Multiple myeloma

MGUS:

Monoclonal gammopathy of uncertain significance

AOPPs:

Advanced oxidation protein products

AGEs:

Advanced glycation end products

ROS:

Reactive oxygen species

NO:

Nitric oxide

MDA/HNE:

Malondialdehyde/4-hydroxynonenal

β2m:

Beta-2 microglobulin

LDH:

Lactate dehydrogenase

ESR:

Erythrocyte sedimentation rate

SOD:

Superoxide dismutase

GPX:

Glutathione peroxidase

RAGEs:

Receptor for advanced glycation end products

Bcl-2:

B cell lymphoma-2

DKK1:

Dickkopf-1

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Acknowledgments

The authors would like to thank Ms. Antonina Donato for the editing of the text.

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Authors and Affiliations

  1. Department of Human Pathology, School and Division of Allergy and Clinical Immunology, University of Messina, Messina, Italy

    Sebastiano Gangemi

  2. Institute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy

    Sebastiano Gangemi

  3. Division of Haematology, University of Messina, Policlinico Universitario G Martino Via Colapesce 20, Messina, Italy

    Alessandro Allegra, Andrea Alonci, Sabina Russo, Giuseppa Penna, Antonino Cannavò, Giacomo Bellomo & Caterina Musolino

  4. Department Farmaco-Biologico, School of Pharmacy, University of Messina, Messina, Italy

    Mariateresa Cristani & Antonio Speciale

  5. Department of Social and Environmental Medicine, Section of Occupational Medicine, University of Messina, Messina, Italy

    Giovanna Spatari

Authors
  1. Sebastiano Gangemi
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  2. Alessandro Allegra
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  3. Andrea Alonci
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  4. Mariateresa Cristani
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  9. Antonino Cannavò
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  10. Giacomo Bellomo
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  11. Caterina Musolino
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Correspondence to Caterina Musolino.

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Responsible Editor: Michael Parnham.

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Gangemi, S., Allegra, A., Alonci, A. et al. Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions. Inflamm. Res. 61, 1063–1067 (2012). https://doi.org/10.1007/s00011-012-0498-7

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  • DOI: https://doi.org/10.1007/s00011-012-0498-7

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