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Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia

Inflammation Research volume 60, pages 429–437 (2011)Cite this article

Abstract

Objective and design

To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model.

Subjects

Twenty-seven adult female sheep.

Treatment

All sheep were subjected to a Salmonella typhosa endotoxin infusion (10 ng/kg/min). After 16 h of endotoxemia, the surviving animals (n = 24) were randomized to (1) an untreated control group, (2) a continuous terlipressin group (2 mg/24 h), or (3) a terlipressin bolus group (1 mg/6 h).

Methods

Hemodynamic variables were measured and blood was withdrawn at specific time points for the assessment of organ functions.

Results

Continuous terlipressin infusion was associated with improved surrogate parameters of myocardial, renal, and hepatic function as compared with terlipressin bolus infusion. Reduced vascular hyperpermeability was evidenced by an attenuated decrease in plasma protein concentrations in sheep treated with continuous terlipressin infusion as compared to bolus injection or no treatment.

Conclusions

Continuous infusion of low-dose terlipressin preserved several surrogate parameters of organ function better than intermittent bolus injections in sheep with systemic inflammation.

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Acknowledgments

The authors thank Katharina Goering, Markus Sporkmann, Mareike Bommert, and Marga Kaiser for expert technical assistance during the experiments. Terlipressin (Haemopressin®) was provided by Prof. Dr. Klaus D. Doehler (Medizinische Hochschule Hannover, Hannover, Germany). This study was supported by Curatis Pharma GmbH and MM GmbH, Hannover, Germany.

Author information

Affiliations

  1. Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany

    Matthias Lange, Christian Ertmer, Sebastian Rehberg, Tim G. Kampmeier, Hugo Van Aken & Martin Westphal

  2. Department of Anesthesiology and Intensive Care, University of Rome “La Sapienza”, Via B. Oriani 2, 00197, Rome, Italy

    Andrea Morelli

  3. Department of Pathology, University of Muenster, Domagkstr. 5, 48149, Muenster, Germany

    Gabriele Köhler

Authors
  1. Matthias Lange
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  2. Christian Ertmer
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  3. Sebastian Rehberg
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  4. Andrea Morelli
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  5. Gabriele Köhler
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  6. Tim G. Kampmeier
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  7. Hugo Van Aken
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  8. Martin Westphal
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Correspondence to Matthias Lange.

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Responsible Editor: Artur Bauhofer.

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Lange, M., Ertmer, C., Rehberg, S. et al. Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia. Inflamm. Res. 60, 429–437 (2011). https://doi.org/10.1007/s00011-010-0299-9

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  • DOI: https://doi.org/10.1007/s00011-010-0299-9

Keywords

  • Sepsis
  • Sheep
  • Vascular leakage
  • Arginine vasopressin