Abstract
Introduction
Systemic inflammation is associated with atrial fibrillation (AF) and inflammatory processes are involved in the pathophysiology of AF. We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with increased risk of AF.
Materials and methods
We included 158 patients with AF and 188 healthy controls. All patients were genotyped for common single nucleotide polymorphisms (SNPs) in selected inflammatory genes.
Results
A case–control analysis of the investigated SNPs (IL1A-889, TNF-308, IL1B-511, IL10-592, IL10-1082, IL18-137 and IL18-607) revealed no significant differences in the frequencies of genotypes between the AF patients and the healthy controls.
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Acknowledgments
The study was supported by grants from “The Danish Heart Foundation (08-10-R68-A2150-B841-22518)”, “The Research Foundation” at the Heart Centre at Rigshospitalet, “Rigshospitalets forskningsudvalg”, “Augustinus Fonden”, “Direktør Ib Henriksens Fond”, “Aase og Ejnar Danielsens Fond”, “Arvid Nilssons Fond”, “Lægernes Forskningsforening af 1891”, “Tove and John Girotti’s Fond”, “Direktør Kurt Bønnelycke og Hustru fru Grethe Bønnelyckes Fond”, “The John and Birthe Meyer Foundation” and “The Danish Arrhythmia Research Centre (DARC)”. The Centre of Inflammation and Metabolism is supported by a grant from the Danish National Research Foundation (# 02-512-55).
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Henningsen, K.M., Olesen, M.S., Ravn, L.S. et al. Inflammatory single nucleotide polymorphisms and the risk of atrial fibrillation: a case control study. Inflamm. Res. 60, 209–211 (2011). https://doi.org/10.1007/s00011-010-0285-2
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DOI: https://doi.org/10.1007/s00011-010-0285-2