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The potential application of nicotinic acetylcholine receptor agonists for the treatment of rheumatoid arthritis

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Abstract

Although the disease-modifying anti-rheumatic drugs (DMARD) have been widely used in clinics, rheumatoid arthritis (RA) is not completely curable so far. Hence, to seek new drugs for the treatment of RA has become a pursuing goal of rheumatologists and orthopedic surgeons. Since the major pathological characteristic of RA is inflammation, the exploration of anti-inflammatory drugs has become a hotspot. Moreover, the anti-inflammatory and anti-nociceptive functions of nicotinic acetylcholine receptors as well as the related mechanisms have been recently discovered. Based on the abovementioned, it is promising that the nicotinic acetylcholine receptor agonists will be applied for the treatment of RA. Following in vitro, in vivo experiments as well as clinical trials will even strengthen this viewpoint and more RA patients will benefit from the application of such agents.

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Authors and Affiliations

  1. The Translational Medicine R&D Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, GuangDong Province, China

    Peng Zhang, Ling Qin & Ge Zhang

  2. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China

    Peng Zhang, Ling Qin & Ge Zhang

Authors
  1. Peng Zhang
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  2. Ling Qin
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  3. Ge Zhang
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Correspondence to Peng Zhang or Ling Qin.

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Responsible Editor: J. Di Battista.

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Zhang, P., Qin, L. & Zhang, G. The potential application of nicotinic acetylcholine receptor agonists for the treatment of rheumatoid arthritis. Inflamm. Res. 59, 415–417 (2010). https://doi.org/10.1007/s00011-010-0160-1

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  • DOI: https://doi.org/10.1007/s00011-010-0160-1

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