Skip to main content

Advertisement

SpringerLink
Log in

Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet’s disease with or without ocular involvement

  • Original Research Paper
  • Published:
Inflammation Research Aims and scope Submit manuscript

Abstract

Purpose

The association of known ACE gene and eNOS gene polymorphisms with BD in a group of Turkish patients with or without ocular involvement has been investigated.

Methods

The ACE and eNOS gene polymorphisms were investigated in 73 BD patients and 90 controls.

Results

The distrubition of “DD”, “ID” and “II” genotypes of the ACE gene were 32 (43.8%), 29 (39.8%) and 12 (16.4%) for BD patients and 32 (35.5%), 35 (38.9%) and 23 (25.6%) for healthy controls. There was no significant difference between the groups (p = 0.140, OR 1.44, CI 0.90–2.30). When Behçet patients with ocular involvement were compared to the control group, statistical significance was found (p = 0.049, OR 2.18, CI 1.00–4.81). The “bb”, “ba”, and “aa” genotype frequencies of the eNOS gene were 48 (65.8%), 23 (31.5%), and 2 (2.7%) for patients with BD and 75 (83.3%), 15 (16.7%), and 0 (0%) for healthy controls, respectively. The significant difference found in allelic frequencies between the two groups (p = 0.011, OR 2.32, CI 1.11–4.87). When Behçet patients with ocular involvement were compared, sharper statistical significance was found (p = 0.001,OR 4.61,CI 1.85–11.52).

Discussion

The ACE gene polymorphism does not play a role in the pathogenesis of BD. The findings of the eNOS gene polymorphisms confirmed the significant association with BD and even more in patients with ocular involvement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet’s disease. N Engl J Med. 1999;21:341(17):1284–91.

    Google Scholar 

  2. Haznedaroglu IC, Ozcebe OI, Ozdemir O, Celik I, Dundar SV, Kirazli S. Impaired haemostatic kinetics and endothelial function in Behcet’s disease. J Intern Med. 1996;240(4):181–7.

    Article  PubMed  CAS  Google Scholar 

  3. Chambers JC, Haskard DO, Kooner JS. Vascular endothelial function and oxidative stress mechanisms in patients with Behcet’s syndrome. J Am Coll Cardiol. 2001;37(2):517–20.

    Article  PubMed  CAS  Google Scholar 

  4. Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Altunbas HH, Urgancioglu M. Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138:373–80.

    Article  PubMed  Google Scholar 

  5. Savage CO, Cooke SP. The role of the endothelium in systemic vasculitis. J Autoimmun. 1993;6(2):237–49.

    Article  PubMed  CAS  Google Scholar 

  6. Farrell AJ, Blake DR. Nitric oxide. Ann Rheum Dis. 1996;55(1):7–20.

    Article  PubMed  CAS  Google Scholar 

  7. Hattori R, Sase K, Eizawa H, Kosuga K, Aoyama T, Inoue R, et al. Structure and function of nitric oxide synthases. Int J Cardiol. 1994;47(Suppl 1):S71–5.

    Article  PubMed  CAS  Google Scholar 

  8. Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res. 1999;15:43(3):521–31.

    Google Scholar 

  9. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM, et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993;15;268(23):17478–88.

    Google Scholar 

  10. Orem A, Vanizor B, Cimsit G, Kiran E, Deger O, Malkoc M. Decreased nitric oxide production in patients with Behcet’s disease. Dermatology. 1999;198(1):33–6.

    Article  PubMed  CAS  Google Scholar 

  11. Osborne NN, Barnett NL, Herrera AJ. NADPH diaphorase localization and nitric oxide synthase activity in the retina and anterior uvea of the rabbit eye. Brain Res. 1993;610:194–8.

    Article  PubMed  CAS  Google Scholar 

  12. Henrion D, Benessiano J, Levy BI. In vitro modulation of a resistance artery diameter by the tissue renin-angiotensin system of a large donor artery. Circ Res. 1997;80(2):189–95.

    PubMed  CAS  Google Scholar 

  13. Kranzhofer R, Schmidt J, Pfeiffer CA, Hagl S, Libby P, Kubler W. Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999;19(7):1623–9.

    PubMed  CAS  Google Scholar 

  14. Mattei MG, Hubert C, Alhenc-Gelas F, Roeckel N, Corvol P, Soubrier F. Angiotensin-I converting enzyme gene is on chromosome 17. Cytogenet Cell Genet. 1989;51:1041.

    Google Scholar 

  15. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med. 1995;16:332(11):706–11.

    Google Scholar 

  16. Molad Y, Gal E, Magal N, Sulkes J, Mukamel M, Weinberger A, et al. Renal outcome and vascular morbidity in systemic lupus erythematosus (SLE): lack of association with the angiotensin-converting enzyme gene polymorphism. Semin Arthritis Rheum. 2000;30(2):132–7.

    Article  PubMed  CAS  Google Scholar 

  17. International Study group for Behçet’s Disease-towards internationally agreed criteria. Br J Rheumatol. 1992;31:299–308.

    Google Scholar 

  18. Erdos EG. Angiotensin I converting enzyme and the changes in our concepts through the years. Hypertension. 1990;16(4):363–70.

    PubMed  CAS  Google Scholar 

  19. Rogerson FM, Chai SY, Schlawe I, Murray WK, Marley PD, Mendelsohn FA. Presence of angiotensin converting enzyme in the adventitia of large blood vessels. J Hypertens. 1992;10(7):615–20.

    Article  PubMed  CAS  Google Scholar 

  20. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86(4):1343–6.

    Article  PubMed  CAS  Google Scholar 

  21. Brasier AR, Li J. Mechanisms for inducible control of angiotensinogen gene transcription. Hypertension. 1996;27:465–75.

    PubMed  CAS  Google Scholar 

  22. Sato H, Akai Y, Iwano M, Kurumatani N, Kurioka H, Kubo A, et al. Association of an insertion polymorphism of angiotensin-converting enzyme gene with the activity of systemic lupus erythematosus. Lupus. 1998;7(8):530–4.

    Article  PubMed  CAS  Google Scholar 

  23. Pullmann R Jr, Lukac J, Skerenova M, Rovensky J, Hybenova J, Melus V, et al. Association between systemic lupus erythematosus and insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene. Clin Exp Rheumatol. 1999;17(5):593–6.

    PubMed  Google Scholar 

  24. Mayer NJ, Forsyth A, Kantachuvesiri S, Mullins JJ, Fleming S. Association of the D allele of the angiotensin I converting enzyme polymorphism with malignant vascular injury. Mol Pathol. 2002;55(1):29–33.

    Article  PubMed  CAS  Google Scholar 

  25. Ozturk MA, Calguneri M, Kiraz S, Ertenli I, Onat AM, Ureten K, et al. Angiotensin-converting enzyme gene polymorphism in Behcet’s disease. Clin Rheumatol. 2004;23(2):142–6.

    Article  PubMed  Google Scholar 

  26. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab. 2000;70(4):241–51.

    Article  PubMed  CAS  Google Scholar 

  27. Wang XL, Sim AS, Wang MX, Murrell GA, Trudinger B, Wang J. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett. 2000;7;471(1):45–50.

    Google Scholar 

  28. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;1;91(5):1314–9.

    Google Scholar 

  29. Raza K, Thambyrajah J, Townend JN, Exley AR, Hortas C, Filer A, et al. Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease? Circulation. 2000;26;102(13):1470–2.

  30. Karasneh JA, Hajeer AH, Silman A, Worthington J, Ollier WE, Gul A. Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet’s disease. Rheumatology. 2005;44(5):614–7.

    Article  PubMed  CAS  Google Scholar 

  31. Yilmaz G, Sizmaz S, Yilmaz ED, Duman S, Aydin P. Aqueous humor nitric oxide levels in patients with Behçet disease. Retina. 2002;22:330–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Genetics, Medical Faculty Zonguldak, Zonguldak Karaelmas University, 67600, Zonguldak, Turkey

    Ahmet Dursun & Savas Baris

  2. Department of Medical Genetics, Meram Medical Faculty Konya, Selcuk University, 42080, Konya, Turkey

    Hatice Gul Durakbasi-Dursun

  3. Department of Dermatology, Baskent University, 42080, Konya, Turkey

    Recep Dursun

  4. Department of Ophthalmology, Saint Louis University, St. Louis, MO, USA

    Levent Akduman

Authors
  1. Ahmet Dursun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hatice Gul Durakbasi-Dursun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Recep Dursun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Savas Baris
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Levent Akduman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmet Dursun.

Additional information

Responsible Editor: G. Wallace.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dursun, A., Durakbasi-Dursun, H.G., Dursun, R. et al. Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet’s disease with or without ocular involvement. Inflamm. Res. 58, 401–405 (2009). https://doi.org/10.1007/s00011-009-0005-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00011-009-0005-y

Keywords

Search

Navigation