Abstract.
Objective:
To test whether IL-10 promoter region polymorphisms are associated with susceptibility to inflammatory bowel disease, we examined the contribution of interleukin- 10 (IL-10) gene polymorphisms to Crohn’s disease (CD) and Ulcerative colitis disease (UC) occurrence and also to CD phenotype.
Materiels and Methods:
SNPs at positions -627 (C > A) and −1117 (G > A) in the IL-10 promoter were determined in a sample of 105 Tunisian patients with IBD (75 CD and 30 UC) and 90 matched healthy controls.
Results:
The 627 CA genotype is associated with ileal location (p = 0.015) and with stricturing (p = 510-3) and penetrating (p = 310-3) presentation of CD. An additive effect between IL10 variants and CARD15 3020 insC mutation (p = 0,006) on severe forms of CD was shown.
Conclusions:
In Tunisian population, the 3020insC insertion in NOD2/CARD15 gene is a marker of susceptibility to CD, while the A allele at position -627 in the IL-10 promoter increases the risk of CD ileal location and severe disease presentation. A genetic epistasis between IL-10 gene polymorphisms and CARD15/NOD2 gene mutation was suggested.
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A. Moussa, S. Ouerhani, K. Bougatef : The authors have collaborated on the same level
Received 29 September 2008; returned for revision 6 November 2008; received from final revision 9 November 2008; accepted by A. Falus 11 November 2008
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Marrakchi, R., Moussa, A., Ouerhani, S. et al. Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population. Inflamm. Res. 58, 155–160 (2009). https://doi.org/10.1007/s00011-008-8265-5
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DOI: https://doi.org/10.1007/s00011-008-8265-5