Abstract.
Objective and design:
We investigated the influence of acute inflammation in skin isograft acceptance.
Methods:
Two mouse lines selected for maximal (AIRMAX) or minimal inflammatory response (AIRMIN) were transplanted with syngeneic skin. Cellular infiltrates and cytokine production were measured 1, 3, 7 or 14 days post-transplantation. The percentage of CD4+CD25+Foxp3+ cells in the lymph nodes was also evaluated.
Results:
Grafts were totally accepted in 100% of AIRMAX and in 26% of AIRMIN mice. In the latter, partial acceptance was observed in 74% of the animals. Emigrated cells were basically PMN and were enhanced in AIRMAX transplants. IL-10 production by graft infiltrating cells showed no interline differences. IFN-γ was increased in AIRMIN grafts at day 14 and lower percentages of CD4+CD25+Foxp3+ cells in the lymph nodes were observed in these mice.
Conclusions:
Our data suggest that differences in graft acceptance might be due to a lack of appropriate regulation of the inflammatory response in AIRMIN mice compromising the self/non-self recognition.
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Received 30 July 2007; returned for revision 10 October 2007; received from final revision 18 October 2007; accepted by G. Wallace 30 November 2007
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Larocca, R., Marguti, I., Cabrera, W. et al. Maximal inflammatory response benefits syngeneic skin graft acceptance. Inflamm. res. 57, 171–177 (2008). https://doi.org/10.1007/s00011-007-7140-0
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DOI: https://doi.org/10.1007/s00011-007-7140-0