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Maximal inflammatory response benefits syngeneic skin graft acceptance

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Abstract.

Objective and design:

We investigated the influence of acute inflammation in skin isograft acceptance.

Methods:

Two mouse lines selected for maximal (AIRMAX) or minimal inflammatory response (AIRMIN) were transplanted with syngeneic skin. Cellular infiltrates and cytokine production were measured 1, 3, 7 or 14 days post-transplantation. The percentage of CD4+CD25+Foxp3+ cells in the lymph nodes was also evaluated.

Results:

Grafts were totally accepted in 100% of AIRMAX and in 26% of AIRMIN mice. In the latter, partial acceptance was observed in 74% of the animals. Emigrated cells were basically PMN and were enhanced in AIRMAX transplants. IL-10 production by graft infiltrating cells showed no interline differences. IFN-γ was increased in AIRMIN grafts at day 14 and lower percentages of CD4+CD25+Foxp3+ cells in the lymph nodes were observed in these mice.

Conclusions:

Our data suggest that differences in graft acceptance might be due to a lack of appropriate regulation of the inflammatory response in AIRMIN mice compromising the self/non-self recognition.

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Authors and Affiliations

  1. Laboratory of Clinical Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    R. Larocca, I. Marguti, L. V. Rizzo & L. Vieira de Moraes

  2. Laboratory of Immunogenetics, Butantan Institute, São Paulo, Brazil

    W. Cabrera & O. Garcia Ribeiro

  3. Laboratory of Medical Investigation (LIM 60), Division of Allergy of Clinical Immunology, University of São Paulo Medical School, São Paulo, Brazil

    L. V. Rizzo

  4. Fundação E. J. Zerbini, São Paulo, Brazil

    L. V. Rizzo

  5. Departamento de Imunologia, Instituto de Ciências Biomédicas IV, Universidade de São Paulo. Av. Prof. Lineu Prestes, 1730, São Paulo, SP, 05508-000, Brazil

    L. Vieira de Moraes

Authors
  1. R. Larocca
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  2. I. Marguti
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  3. W. Cabrera
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  4. O. Garcia Ribeiro
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  5. L. V. Rizzo
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  6. L. Vieira de Moraes
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Corresponding author

Correspondence to L. Vieira de Moraes.

Additional information

Received 30 July 2007; returned for revision 10 October 2007; received from final revision 18 October 2007; accepted by G. Wallace 30 November 2007

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Larocca, R., Marguti, I., Cabrera, W. et al. Maximal inflammatory response benefits syngeneic skin graft acceptance. Inflamm. res. 57, 171–177 (2008). https://doi.org/10.1007/s00011-007-7140-0

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  • DOI: https://doi.org/10.1007/s00011-007-7140-0

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