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Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

Inflammation Research volume 56, pages 402–408 (2007)Cite this article

Abstract.

Objective:

Eosinophils and cytokines are implicated in the pathogenesis of allergic diseases. In the present study, we investigate the anti-inflammatory effect of quercetin and isoquercitrin in a murine model of asthma.

Methods:

BALB/c mice were immunized (ovalbumin/aluminum hydroxide, s. c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice received daily gavages of isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) was administered as a positive control. Leucocytes were analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) was analyzed in BALF and lung homogenates.

Results:

In animals receiving isoquercitrin or quercetin, eosinophil counts were lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate were lower only in isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed.

Conclusion:

Quercetin and isoquercitrin are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.

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Authors and Affiliations

  1. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Ribeirão Preto, Brasil

    A. P. Rogerio, C. Fontanari, E. V. G. da Silva & L. H. Faccioli

  2. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14040-903, Brasil

    A. Kanashiro & Y. M. Lucisano-Valim

  3. Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14040-900, Brasil

    E. G. Soares

Authors
  1. A. P. Rogerio
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  2. A. Kanashiro
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  3. C. Fontanari
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  4. E. V. G. da Silva
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  5. Y. M. Lucisano-Valim
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  6. E. G. Soares
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  7. L. H. Faccioli
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Corresponding author

Correspondence to L. H. Faccioli.

Additional information

Received 7 July 2006; returned for revision 12 September 2006; returned for final revision 12 March 2007; accepted by A. Falus 2 May 2007

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Rogerio, A.P., Kanashiro, A., Fontanari, C. et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm. res. 56, 402–408 (2007). https://doi.org/10.1007/s00011-007-7005-6

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  • DOI: https://doi.org/10.1007/s00011-007-7005-6

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