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The effects of fructose-1,6-bisphosphate and dexamethasone on acute inflammation and T-cell proliferation

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Abstract.

Objective and design

Chronic glucocorticoid treatment is associated with pharmacological resistance. We investigated the auxiliary effects of fructose-1,6-bisphosphate (FBP) on dexamethasone (DEX)-related modulation of inflammation and T-cell proliferation.

Methods

Acute inflammation (pleurisy) was induced by injection of carrageenan into the pleural cavity of rats that were treated in vivo with DEX s. c. and FBP i. p. Peripheral blood mononuclear cells were isolated and T-cell sensitivity to FBP and DEX was evaluated in vitro.

Results

FBP and DEX reduced the exudate volume, protein concentration and neutrophils in the pleural cavity. However no synergistic effects were observed when these compounds were tested simultaneously. In contrast, both compounds dose-dependently and synergistically suppressed T-cell proliferation.

Conclusion

These data suggest that FBP may be beneficial as auxiliary drug for the treatment of patients with acquired glucocorticoid resistance.

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Authors and Affiliations

  1. Laboratory of Cellular and Molecular Immunology, Institute of Biomedical Research, Hospital São Lucas, PUCRS, Av. Ipiranga 6690, 2 andar – Caixa Postal 1429. 90., 610-000, Porto Alegre, RS, Brazil

    R. Pestana Lopes, T. Preissler & M. E. Bauer

  2. Laboratory of Biophysics, Pontifícia Universidade Católica do Rio Grande do Sul, Rio Grande do Sul, Brazil

    A. Lunardelli, C. E. Leite, F. Bordignon Nunes & J. Rodrigues de Oliveira

  3. Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6681, 12C, PO Box 1429, Porto Alegre, RS, Brazil

    F. Bordignon Nunes, J. Rodrigues de Oliveira & M. E. Bauer

  4. Department of Pharmacology, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP, Brazil

    J. C. F. Alves-Filho

Authors
  1. R. Pestana Lopes
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  2. A. Lunardelli
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  3. T. Preissler
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  4. C. E. Leite
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  5. J. C. F. Alves-Filho
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  6. F. Bordignon Nunes
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  7. J. Rodrigues de Oliveira
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  8. M. E. Bauer
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Corresponding author

Correspondence to M. E. Bauer.

Additional information

Received 7 November 2005; returned for revision 15 January 2006; accepted by I. Ahnfelt-Rønne 29 March 2006

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Lopes, R.P., Lunardelli, A., Preissler, T. et al. The effects of fructose-1,6-bisphosphate and dexamethasone on acute inflammation and T-cell proliferation. Inflamm. res. 55, 354–358 (2006). https://doi.org/10.1007/s00011-006-6044-8

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  • DOI: https://doi.org/10.1007/s00011-006-6044-8

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