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Inflammation Research

, Volume 54, Issue 7, pp 295–303 | Cite as

Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia

  • C. Penido
  • K. A. Costa
  • R. J. Pennaforte
  • M. F. S. Costa
  • J. F. G. Pereira
  • A. C. Siani
  • M. G. M. O. HenriquesEmail author
Original Research Paper

Abstract.

Objective: We investigated the anti-allergic and analgesic properties of an oil and a derived fraction of tetranortriterpenoids (TNTP) obtained from the seeds of Carapa guianensis Aublet.

Materials and methods: Pleurisy, paw and ear edema were induced in Swiss and C57/Bl10 mice mice, whereas thermal hyperalgesia was assessed in Wistar rats (n = 6−10 per group). Values of p < 0.05 were regarded as significant.

Results: C. guianensis oil (100 to 400 mg/kg, p.o.) and TNTP (12.5 to 100 mg/kg, p.o.) inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice. TNTP (12.5 to 100 mg/kg, p.o.) also inhibited paw edema induced by histamine, PAF and bradykinin. TNTP (100 mg/kg, p.o.) inhibited prostaglandin E2 generation in the pleural cavity in response to antigenic challenge. Moreover, C. guianensis oil (100 to 400 mg/kg) and TNTP (12.5 to 100 mg/kg) decreased OVA- and histamine-induced hyperalgesia.

Conclusion: Taken together, these findings demonstrate the anti-edematogenic and analgesic effects of C. guianensis oil, and points out TNTP as the responsible bioactive compounds.

Key words.

Carapa guianensis Aubl. Allergy Pleurisy Edema Hyperalgesia Inflammatory mediators 

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Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  • C. Penido
    • 1
  • K. A. Costa
    • 1
  • R. J. Pennaforte
    • 1
  • M. F. S. Costa
    • 1
  • J. F. G. Pereira
    • 2
  • A. C. Siani
    • 2
  • M. G. M. O. Henriques
    • 1
    Email author
  1. 1.Departamento de Farmacologia Aplicada, Far-ManguinhosFundação Oswaldo CruzRio de JaneiroBrazil
  2. 2.Departamento de Produtos Naturais, Far-ManguinhosFundação Oswaldo CruzRio de JaneiroBrazil

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