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Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Chronic inflammation of the gastrointestinal system is mediated by both the immune system activity and homeostasis, mainly through releasing of various cytokines and chemokines, as well as the transmigration of the inflammatory cells to the affected site. In between, macrophages are key mediators of the immune system, nearly located all over the gastrointestinal tract. Macrophages have vital influence on the inflammatory condition with both pro-inflammatory and anti-inflammatory functions. Their polarization status has been linked to numerous metabolic disorders such as inflammatory bowel disease (IBD). The equilibrium between the phenotypes and functions of inflammatory M1 and anti-inflammatory M2 cells is regulated by both extracellular and intracellular stimuli, determining how the disease progresses. Thereby, factors that interchange such balance in the direction of increasing M2 macrophages offer unique approaches for future management of IBD. This study reflects the novel IBD treatment targets via the immune system’s pathway, reporting the latest treatments that regulate the M1/M2 macrophages distribution in a way to favor IBD.

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Author notes

  1. Seyede Sara Seyedizade and Khashayar Afshari contributed equally in this work.

Authors and Affiliations

  1. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

    Seyede Sara Seyedizade, Saba Bayat, Fatemeh Rahmani & Amir Hossein Abdolghaffari

  2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Khashayar Afshari

  3. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran

    Saeideh Momtaz & Amir Hossein Abdolghaffari

  4. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Saeideh Momtaz & Amir Hossein Abdolghaffari

  5. Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Saeideh Momtaz & Amir Hossein Abdolghaffari

  6. Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, P.O Box: 14194, Tehran, Iran

    Nima Rezaei

  7. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei

  8. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Amir Hossein Abdolghaffari

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  1. Seyede Sara Seyedizade
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Seyedizade, S.S., Afshari, K., Bayat, S. et al. Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease. Arch. Immunol. Ther. Exp. 68, 10 (2020). https://doi.org/10.1007/s00005-020-00576-4

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