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HLA-A and -B Type and Haplotype Frequencies in IgG Subclass Deficiency Subgroups

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal IgG1/IgG3) and controls (1,321 for types; 751 for haplotypes). We selected types and haplotypes because their uncorrected frequencies differed significantly from controls in a previous adult IgGSD/common variable immunodeficiency cohort: A*24; B*14; B*35; B*40; B*49; B*50; B*58; B*62; A*01,B*08; A*02,B*44; A*02,B*60; A*03,B*07; A*03,B*14; A*03,B*44; A*31,B*40; and A*32,B*14. We used χ2 analysis (2 × 4 tables) to identify frequency differences across three subgroups and controls. If the null hypothesis was rejected (p < 0.05), we computed 2 × 2 χ2 tables to compare six combinations of subgroup and control frequencies [Bonferroni p < 0.0083 (< 0.05/6)]. Mean age was 48 ± 13 years; 82.2% were women. B*35 and B*40 frequencies were higher in subnormal IgG1 than subnormal IgG3 patients (0.1000 vs. 0.0248 and 0.0571 vs. 0.0083, respectively; p ≤ 0.0061). B*62 frequencies were lower in three IgGSD subgroups than controls (p < 0.0001, respectively). A*02, B*44 frequency was higher in subnormal IgG1/IgG3 patients than controls (0.1282 vs. 0.0632, respectively; p = 0.0024). A*02, B*60 frequency was lower in subnormal IgG3 patients than controls (0.0 vs. 0.0233, respectively; p = 0.0051). HLA-B*35 and -B*40 frequencies differ significantly between some IgGSD subgroups. B*62, A*02, B*44, and A*02, B*60 frequencies differ significantly between some IgGSD subgroups and controls.

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Abbreviations

CVID:

Common variable immunodeficiency

HLA:

Human leukocyte antigen

Ig:

Immunoglobulin

IgGSD:

IgG subclass deficiency

MHC:

Major histocompatibility complex

SD:

Standard deviation

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Acknowledgements

This work was supported in part by Southern Iron Disorders Center.

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Authors

Contributions

All authors contributed equally to this work. JCB and LFB conceived the study. JaCB and JCB compiled patient data and performed statistical analyses. RTA contributed control data. JCB drafted the manuscript. All authors contributed to the manuscript and approved its final form.

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Correspondence to James C. Barton.

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None of the authors has a conflict of interest to report.

Ethical approval

This work was performed according to the principles of the Declaration of Helsinki (World Medical Association 2013). Western Institutional Review Board provided an exemption under 45 CFR 46.101(b) (4) pertinent to this study on 18 October 2018 (submission 2535878-44170911; 2 October 2018). Obtaining informed consent was not required because this study involved retrospective chart review and analyses of observations recorded in routine medical care and does not include personal identifier information.

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Barton, J.C., Barton, J.C., Bertoli, L.F. et al. HLA-A and -B Type and Haplotype Frequencies in IgG Subclass Deficiency Subgroups. Arch. Immunol. Ther. Exp. 68, 14 (2020). https://doi.org/10.1007/s00005-020-00572-8

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  • DOI: https://doi.org/10.1007/s00005-020-00572-8

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