Adaptive Immune Cell Dysregulation and Role in Acute Pancreatitis Disease Progression and Treatment
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Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. In this review, we examine the literature on the adaptive immune cells in AP, the prognostic value of these cells in stratifying patients into appropriate care and treatment strategies based on cell frequency in different AP severities are discussed.
KeywordsAcute pancreatitis Adaptive immune cells
Compensatory anti-inflammatory response syndrome
Infectious pancreatic necrosis
Systemic inflammatory response syndrome
This Research was supported by Faculty of Health Sciences University of the Witwatersrand Individual Research Grant 001.283.8441101.5121105.5142 and Seed funding Grant 001 251 8441101 5121105 000000 0000000000 4550. The authors would like to thank Drs M. Nel and J. Devar for critical reading of the manuscript.
Compliance with Ethical Standards
Conflict of interest
The authors declare no competing interests.
- Dionigi R, Rovera F, Dionigi G et al (2006) Infected pancreatic necrosis. Surg Infect 7(Suppl 2):S49–S52Google Scholar
- Fakhari S, Abdulmohammadi K, Panahi Y et al (2015) Flow cytometric analysis of inflammatory cells in experimental acute pancreatitis. Arch Med Lab Sci 1:93–99Google Scholar
- Gul’muradova NT, Geinits AV, Ziazin S (2012) The characteristics of cell and humoral immunity in patients with acute pancreatitis under impact of cold laser radiation. Klin Lab Diagn 7:46–49Google Scholar
- Halacheva K, Minkov G, Yovtchev Y et al (2014) Changes in peripheral blood lymphocyte populations in patients with acute pancreatitis. Trakia J Sci 12:50–54Google Scholar
- Kay PS, Smith M, Brand M (2017) The initiating immune response of acute pancreatitis may be mediated by the T-helper 17 pathway. JOP J Pancreas 18(1):33–37Google Scholar
- Parzyan G, Geinits A (2001) Treatment of acute pancreatitis with mexidol and low-intensity laser radiation. In: Low-Level Laser Therapy, 2001. In: Proceedings of the SPIE, vol 4422, pp 92–97. https://doi.org/10.1117/12.425521
- Zheng X, Li S-B, Wang Y et al (2010) Changes of T lymphocyte subsets before and after treatment of acute pancreatitis and its clinical significance [J]. Mod Med J 4:027Google Scholar
- Zhulai GA, Oleinik EK, Ostrovskii KA et al (2014) Alterations of lymphocyte subsets and indicators of immune suppression in patients with acute pancreatitis. Eksp Klin Gastroenterol 9:21–25Google Scholar