Transcription Factor NF-κB: An Update on Intervention Strategies

Abstract

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.

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Acknowledgments

We would like to thank Tania Hicks, Gagandeep Kaur and Dhirendra P. Singh from Environmental Toxicology PhD Program, Southern University and A&M College, Baton Rouge, Louisiana 70813 for critical reading of the manuscript. This work was supported by Young Clinical Scientist Award from the Flight Attendant Medical Research Institute (FAMRI- 123253_YCSA_Faculty); NIH R15 (7 R15 ES023151 02); Southern University System Foundation Grant (COSC0016) and Louisiana Biomedical Research Network (LBRN) Startup Funds 2P20GM103424-14 (Subaward No. 100011) to SB.

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Correspondence to Sanjay Batra.

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Panday, A., Inda, M.E., Bagam, P. et al. Transcription Factor NF-κB: An Update on Intervention Strategies. Arch. Immunol. Ther. Exp. 64, 463–483 (2016). https://doi.org/10.1007/s00005-016-0405-y

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Keywords

  • NF-κB
  • Asthma
  • COPD
  • HIV
  • HSV
  • Cancer
  • DNA damage