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Platelet influence on T- and B-cell responses

Archivum Immunologiae et Therapiae Experimentalis volume 57, pages 235–241 (2009)Cite this article

Abstract

Understanding the adaptive immune response is an area of research critically important in medicine. Several positive regulators of B- and T-cell activation exist to eliminate pathogens, in which CD40 ligand (CD154) plays a fundamental role. It is well documented that CD154 expressed by CD4 T helper cells can be critical in the proper activation of dendritic cells for the productive stimulation of CD8 T cells and is required for proper T-dependent B-cell immunity. However, platelets are an abundant and systemic source of CD154. While classically known to be important for hemostasis and inflammation, several lines of evidence suggest that platelet-derived ligands can modulate the adaptive immune compartment.

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Affiliations

  1. Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA

    Jennifer M. Sowa, Scott A. Crist, Timothy L. Ratliff & Bennett D. Elzey

  2. Purdue Cancer Center, Purdue University, West Lafayette, IN, USA

    Timothy L. Ratliff

  3. Department of Urology, Indiana University, Indianapolis, IN, USA

    Bennett D. Elzey

  4. Wishard Memorial Hospital, Room OPW 320, 1001 W. 10th St., Indianapolis, IN, 46202, USA

    Bennett D. Elzey

Authors
  1. Jennifer M. Sowa
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  2. Scott A. Crist
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  3. Timothy L. Ratliff
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  4. Bennett D. Elzey
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Correspondence to Bennett D. Elzey.

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Sowa, J.M., Crist, S.A., Ratliff, T.L. et al. Platelet influence on T- and B-cell responses. Arch. Immunol. Ther. Exp. 57, 235–241 (2009). https://doi.org/10.1007/s00005-009-0032-y

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Keywords

  • platelets
  • CD154
  • T cells
  • B cells