Abstract
Antibiotic residues in products of animal origin are of great concern to regulatory agencies and consumers worldwide. Indiscriminate use of antibiotics has promoted the development of bacterial resistance, which has become an international issue. The occurrence of chloramphenicol (CAP) was evaluated in 84 raw milk samples from the reception platform of a dairy industry at Northern Parana, Brazil and this rate of occurrence was used to estimate the extent of exposure of CAP to the consumer. In the present study CAP determination was carried out by ELISA and found in 28.6 % of the samples. Levels ranged from not detected to 3953.39 ng/L. Despite prohibition of CAP by Brazilian Legislation, residues of CAP were detected in milk. The estimated daily intake (EDI) of CAP was evaluated, and the average intake ranged from 0.092 ng/kg body weight (b.w.) for adolescents to 0.084 ng/kg b.w. for the elderly. To the best of our knowledge, this is the first report on estimated CAP dietary exposure from Parana, Brazil.
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Berrada H, Font G (2011) Antibiotics. In: Nollet LML, Toldra FL (eds) Handbook of analysis of edible animals by-products. CRC Press, Boca Raton
Bilandžić N, Kolanović BS, Varenina I, Scortichini G, Annunziata L, Brstilo M, Rudan N (2011) Veterinary drug residues determination in raw milk in Croatia. Food Control 22:1941–1948
Brasil (2003a) Instrução Normativa n° 9, de 27 de junho de 2003. Diário Oficial da União, Brasília, 30 de junho de 2003
Brasil (2003b) Resolução RDC n° 253, de 16 de setembro de 2006. Dispõe sobre a criação do Programa de Análise de Resíduos de Medicamentos Veterinários em Alimentos de Origem Animal—PAMVet. Diário Oficial da União, Brasília, 18 setembro 2003
Brasil (2009) Programa de análise de resíduos de medicamentos veterinários em alimentos de origem animal—PAMVet. Relatório 2006–2007. http://portal.anvisa.gov.br/wps/wcm/connect/72efdb0047458ad19441d43fbc4c6735/PAMVET.pdf?MOD=AJPERES. Accessed 2 December, 2014
Fodey TL, Murilla G, Cannavan A, Elliott C (2007) Characterization of antibodies to chloramphenicol, produced in different species by enzyme-linked immunosorbent assay and biosensor technologies. Anal Chim Acta 592:51–57
IBGE (2011) Instituto Brasileiro de Geografia e Estatística. Pesquisa de orçamentos familiares 2008–2009. http://www.ibge.gov.br/home/estatistica/populacao/condicaodevida/pof. Accessed 24 June, 2015
Mir SA, Abbas Z (2010) Chloramphenicol: a come back. JK Sci 12:153
Oliveira RC, Bando E, Machinski M Jr (2007) Ocorrência de cloranfenicol em leite pasteurizado comercializado no Estado do Paraná. Acta Science Health Sci 29:59–62
Vieira TSWJ, Ribeiro MR, Nunes MP, Machinski Junior M, Pontes Netto D (2012) Detecção de resíduos de antibióticos em amostras de leite pasteurizado do Estado do Paraná. Brasil. Semina Ciências Agrárias 33(2):791–796
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Sifuentes dos Santos, J., Botaro, B.G., da Costa Ribeiro, A.B. et al. Chloramphenicol residues found in milk processed in Northern Parana, Brazil. J. Verbr. Lebensm. 11, 79–81 (2016). https://doi.org/10.1007/s00003-015-0975-3
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DOI: https://doi.org/10.1007/s00003-015-0975-3