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Serum creatine phosphokinase in thyroid disorders

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Abstract

The decreased serum levels of triiodothyroinine (T3) and thyroxine (T4) in hypothyroid patients is well established but whether there is any correlation of creatinephosphokinase (CPK) with hypothyroidism is not well established. There is a paucity of reference on this study. Therefore a study of serum CPK and thyroid profile was carried out in thyroid diseases. In hypothyroid patients T3, T4 levels in serum were found to be lowered with an increase level of thyroid stimulating hormone (TSH) associated with marked rise in serum CPK level. In hyperthyroid patients serum levels of T3, T4 were found to be increased with decrease in TSh with significant decrease in creatine phosphokinase level. Serum creatine phosphokinase levels thus show an inverse relation with serum T3, T4 levels.

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References

  1. Finsterer, J. Stellberger, C., Grossege, C., Koroiss, A. (1999): Hypothyroid myopathy with unusually high serum creatine kinase. Hormone Res. 52(4), 205–208.

    Article  PubMed  CAS  Google Scholar 

  2. Wan Nazaimoon, W.M., Siano, F.S., Sheriff, I.H., Faridah, I., Khalid, IA (2001): Serum creatine kinase an adjunct unit biochemical index of subclinical thyrotoxicosis. Ann. Clin. Biochem. 38(Pt-l), 57–8.

    Article  PubMed  CAS  Google Scholar 

  3. Graig, F.A. and Ross, G. (1963): Serum creatine phosphokinase in thyroid disease. Metabolism 12(1), 57–59.

    PubMed  CAS  Google Scholar 

  4. Graig, F.A. and Smith, J.C. (1965): Serum creatine phosphokinase activity in altered thyroid states. J. Clin. Endocri. 25, 723.

    Article  CAS  Google Scholar 

  5. Goldman, J.et al. (1977) High elevations of creatine phosphokinase in hypothyroidism. An isoenzyme Analysis. JAMA 238, 325–326.

    Article  PubMed  CAS  Google Scholar 

  6. Doran, G.R. (1978): Serum enzymes disturbances in thyrotoxicosis and myxoedema. J. Royal Society of Medicine 71, 189–193.

    CAS  Google Scholar 

  7. Mehta, P.J.et al. (1982): Serum enzyme in primary hypothyroidism. Ind. Jr. Path. Microbiol. 25(2), 113–116.

    CAS  Google Scholar 

  8. Vijejon, V.K.et al. (1979): Comparative value of creatine-phosphokinase in acute myocardial infarction. Ind. Heart. J. 31(12), 84–87.

    Google Scholar 

  9. Chung, M.A.et al. (1979): Metabolism of the isolated perfused rabbit heart III energy store and creatine phosphokinase release during prolonged reoxygenation of atrial packing. Pharma 57(10), 1058–66.

    Google Scholar 

  10. Grande, P.et al. (1981): Acute myocardial infarct size estimated by serum creatine phosphokinase determinations: Clinical accuracy and prognostic relevance utilizing a practical modification of the isoenzyme approach. Am. Heart J. 101(5), 582–586.

    Article  PubMed  CAS  Google Scholar 

  11. Hughes, B.P. (1962): A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera Clin. Chim. Acta 7, 597–603.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, J.L.N. Medical College, 305001, Ajmer, Raj.

    Rashmi Ranka (Assistant Professor) & Rati Mathur

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  1. Rashmi Ranka
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  2. Rati Mathur
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Ranka, R., Mathur, R. Serum creatine phosphokinase in thyroid disorders. Indian J Clin Biochem 18, 107–110 (2003). https://doi.org/10.1007/BF02867676

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  • DOI: https://doi.org/10.1007/BF02867676

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