Abstract
Objective
To study the relationship between the expression of VEGF, Flk-1 and Flt-1 proteins and clinical pathology in hepatocellular carcinoma.
Methods
The expression of VEGF, Flk-1 and Flt-1 proteins in hepatocellular carcinomas from 60 patients was determined by immunohistochemistry (ABC method) and VEGF expression in relation to the clinicopathology evaluated.
Results
The positive rates of VEGF, Flk-1 and Flt-1 protein expression were 81.3%, 88.3%, 80.0% in tumor tissues, respectively, rates which were significantly higher than those in normal liver tissue (P<0.05). The expression of VEGF protein was correlated with the histologic grade and metastases of the tumors.
Conclusion
The results showed that, in hepatocellular carcinoma, a higher expression of VEGF protein was associated with a higher degree of malignancy and a greater tendency for metastases. VEGF, Flk-1 and Flt-1 play an important role in tumourgenesis.
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Additional information
The project was funded by the Tianjin Natural Science Grant (No. 01361561).
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Hao, J., Li, H., Qin, Y. et al. Relationship between the expression of VEGF, Flk-1 and Flt-1 proteins and clinicopathology in hepatocellular carcinoma. Chin. J. Clin. Oncol. 1, 412–416 (2004). https://doi.org/10.1007/BF02761736
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DOI: https://doi.org/10.1007/BF02761736