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Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

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Abstract

The skin, as the body's main protection barrier from the environment, has an intrinsic self-repairable nature. However, proper wound healing only occurs under appropriate conditions. Skin wounds represent an economic burden on healthcare systems worldwide. Recent research has focused on developing new therapies, especially for chronic wounds. Among them, spray-applied therapies have emerged as a promising strategy for allowing deeper penetration of the products, better conformability, easiness of application, lower discomfort for the patient, and lower risk of contamination during application. Specifically, sprayable wound dressings have been getting attention for enabling the treatment of severe cases or hard-to-heal wounds by incorporating different bioactive agents. Organic and inorganic compounds, natural extracts, signaling compounds, and live human cells have been investigated. In this context, this review summarizes the main findings of recently developed spray-applied bioactive wound dressings.

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Acknowledgements

We acknowledge the support from the National Council for Scientific and Technological Development (CNPq, Brazil, Process #314724/2021-4), the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil, Finance Code 001) and the São Paulo Research Foundation (FAPESP, Brazil, Process #21/00781-9).

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  1. Department of Materials Engineering and Bioprocess, School of Chemical Engineering, University of Campinas, Campinas, São Paulo, Brazil

    Ana Paula Mayumi Nozaki & Ângela Maria Moraes

  2. School of Nursing, University of Campinas, Campinas, São Paulo, Brazil

    Maria Helena de Melo Lima

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Nozaki, A.P.M., de Melo Lima, M.H. & Moraes, Â.M. Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects. Biomedical Materials & Devices 1, 569–586 (2023). https://doi.org/10.1007/s44174-022-00047-8

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