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D-amino acid oxidase: structure, catalytic mechanism, and practical application

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Abstract

D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous system, and aging in mammals. DAAO from yeasts Rhodotorula gracilis and Trigonopsis variabilis are used to convert cephalosporin C into 7-aminocephalosporanic acid, the precursor of other semi-synthetic cephalosporins. This review summarizes the recent data on the enzyme localization, physiological role, gene cloning and expression, and the studies on the enzyme structure, stability, catalytic mechanism, and practical applications.

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Abbreviations

DAAO:

D-amino acid oxidase

DASPO:

D-aspartate oxidase

pkDAAO:

pig kidney D-amino acid oxidase

RgDAAO:

D-amino acid oxidase from Rhodotorula gracilis

TvDAAO:

D-amino acid oxidase from Trigonopsis variabilis

7-ACA:

7-aminocephalosporanic acid

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Authors and Affiliations

  1. Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, 119992, Moscow, Russia

    V. I. Tishkov & S. V. Khoronenkova

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  1. V. I. Tishkov
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  2. S. V. Khoronenkova
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Correspondence to V. I. Tishkov.

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Translated from Biokhimiya, Vol. 70, No. 1, 2005, pp. 51–67. Original Russian Text Copyright © 2005 by Tishkov, Khoronenkova.

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Tishkov, V.I., Khoronenkova, S.V. D-amino acid oxidase: structure, catalytic mechanism, and practical application. Biochemistry (Moscow) 70, 40–54 (2005). https://doi.org/10.1007/PL00021754

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