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Analysis of Bone Mineral Content in Horizontally HIV-Infected Children Naïve to Antiretroviral Treatment

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Abstract

Low bone mass is a frequent finding in HIV-infected individuals. Reduced bone mass has been found in vertically infected children who are receiving antiretroviral treatment. Little is known about bone mass in horizontally infected young patients who are naïve to antiretroviral therapy. We measured the bone mineral content (BMC) at the lumbar spine and in the whole skeleton by using dual-energy X-ray absorptiometry (DXA) in 16 HIV-infected children (age 9.3 ± 3.9 years) naïve to antiretroviral treatment, and in 119 healthy children (age 9.7 ± 3.3 years). Thirteen patients were also pair-matched by anthropometric measures, sex, and age with healthy children. Median spine BMC of HIV-infected children was 14.9 g (8.2–39.2 g), and whole body BMC was 1106.1 g (55.5–2344.1 g). Spine BMC of healthy children was 18.6 g (6.8–52.2 g), and whole body BMC was 1213.5 g (541.0–2722.0 g). Multivariate analysis showed a mean difference of spine BMC values of 0.004 g (P = 0.64) between the two groups. Similarly, the whole body BMC difference between the two groups (0.001 g) was not statistically significant (P = 0.55). Mean spine BMC measurements in the case-control evaluation were 21.1 g (9.7 g) (patients), and 22.3 g (6.9 g) (controls). Whole body BMC measurements of patients and controls were 1258.5 g (539.6 g) and 1311.1 g (479.2 g), respectively. In both cases the differences were not significant. The duration of HIV infection did not relate to BMC values. In conclusion, horizontally HIV-infected children naïve to antiretroviral therapy have bone mineral measurements comparable to those of healthy children.

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References

  1. S Serrano ML Mariñoso JC Soriano J Rubiés-Prat J Aubia J Coll J Bosch L Rio ParticleDel J Vila A Goady M Nacher (1995) ArticleTitleBone remodelling in human immunodeficiency virus-1−infected patients A histomorphometric study. Bone 16 185–191 Occurrence Handle1:STN:280:DyaK2M3nsFGqtA%3D%3D Occurrence Handle7756046

    CAS  PubMed  Google Scholar 

  2. NIJ Paton DC Macallan GE Griffin M Pazianas (1997) ArticleTitleBone mineral density in patients with human immunodeficiency virus infection Calcif Tissue Int 61 30–32 Occurrence Handle1:CAS:528:DyaK2sXktV2gtr0%3D Occurrence Handle10.1007/s002239900288

    Article  CAS  Google Scholar 

  3. P Tebas WG Powderly S Claxton D Marin W Tantisiriwat SL Teitelbaum KE Yarasheski (2000) ArticleTitleAccelerated bone and mineral loss in HIV-infected patients receiving potent antiretroviral therapy AIDS 14 F63–F67 Occurrence Handle1:CAS:528:DC%2BD3cXis1egu7w%3D Occurrence Handle10.1097/00002030-200003100-00005

    Article  CAS  Google Scholar 

  4. A Carr J Miller JA Eisman DA Cooper (2001) ArticleTitleOsteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy AIDS 15 703–709 Occurrence Handle1:STN:280:DC%2BD3M3nt1KisQ%3D%3D Occurrence Handle10.1097/00002030-200104130-00005

    Article  CAS  Google Scholar 

  5. WP Fairfield JS Finkelstein A Klibanski SK Grinspoon (2001) ArticleTitleOsteopenia in eugonadal men with acquired immune deficiency syndrome wasting syndrome J Clin Endocrinol Metab 86 2020–2026 Occurrence Handle1:CAS:528:DC%2BD3MXjs1Omsbc%3D Occurrence Handle11344201

    CAS  PubMed  Google Scholar 

  6. AL Moore A Vashisht CA Sabin A Mocroft S Madge AN Phillips JWW Studd MA Johnson (2001) ArticleTitleReduced bone mineral density in HIV-positive individuals AIDS 15 1731–1733 Occurrence Handle1:STN:280:DC%2BD3Mvpsl2msw%3D%3D Occurrence Handle10.1097/00002030-200109070-00019

    Article  CAS  Google Scholar 

  7. J Gold N Pocock Y Li InstitutionalAuthorNameAlbion St Centre Osteoporosis and HIV Study group (2002) ArticleTitleBone mineral density abnormalities in patients with HIV infection J Acquir Immune Defic Syndr 30 131–132 Occurrence Handle10.1097/00126334-200205010-00020

    Article  Google Scholar 

  8. S Loiseau-Pérès C Delaunay S Poupon E Lespessailles N Ballouche P Arsac CL Benhamou (2002) ArticleTitleOsteopenia in patients infected by the human immunodeficiency virus A case control study. Joint Bone Spine 69 482–485 Occurrence Handle10.1016/S1297-319X(02)00433-5

    Article  Google Scholar 

  9. J Teichmann E Stephan T Discher U Lange K Fedrelin H Stracke G Friese J Lohmeyer RG Bretzel (2003) ArticleTitleOsteopenia in HIV-infected women prior to highly active antiretroviral therapy J Infect 46 221–227 Occurrence Handle1:STN:280:DC%2BD3s3nt1Gksg%3D%3D Occurrence Handle10.1053/jinf.2002.1109

    Article  CAS  Google Scholar 

  10. KO O’Brien M Razavi RA Henderson B Caballero KJ Ellis (2001) ArticleTitleBone mineral content in girls perinatally infected with HIV Am J Clin Nutr 73 821–826 Occurrence Handle10.1093/ajcn/73.4.821

    Article  Google Scholar 

  11. S Mora N Sala D Bricalli G Zuin G Chiumello A Viganò (2001) ArticleTitleBone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapy AIDS 15 1823–1829 Occurrence Handle1:CAS:528:DC%2BD3MXnvVantrc%3D Occurrence Handle10.1097/00002030-200109280-00011

    Article  CAS  Google Scholar 

  12. SM Arpadi M Horlick J Thornton PA Cuff J Wang DP Kotler (2002) ArticleTitleBone mineral content is lower in prepubertal HIV-infected children J Acquir Immune Defic Syndr 29 450–454 Occurrence Handle10.1097/00042560-200204150-00004

    Article  Google Scholar 

  13. S Mora I Zamproni S Beccio R Bianchi V Giacomet A Viganò (2004) ArticleTitleLongitudinal changes of bone mineral density and metabolism in antiretroviral-treated HIV-infected children J Clin Endocrinol Metab 89 24–28 Occurrence Handle1:CAS:528:DC%2BD2cXmvFelug%3D%3D Occurrence Handle10.1210/jc.2003-030767

    Article  CAS  Google Scholar 

  14. InstitutionalAuthorNameCDC (1992) ArticleTitle1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults MMWR Morb Mortal Wkly Rep 41 IssueIDRR-17 1–5

    Google Scholar 

  15. InstitutionalAuthorNameCDC (1994) ArticleTitleRevised classification system for human immunodeficiency virus infection in children less than 13 years of age MMWR Morb Mortal Wkly Rep 43 IssueIDRR-12 1–10

    Google Scholar 

  16. CF Njeh SB Samat A Nightingale EA McNeil CM Boivin (1997) ArticleTitleRadiation dose and in vitro precision in paediatric bone mineral density measurement using dual X-ray absorptiometry Br J Radiol 70 719–727 Occurrence Handle1:STN:280:DyaK2szovVKmsg%3D%3D Occurrence Handle10.1259/bjr.70.835.9245884

    Article  CAS  Google Scholar 

  17. Mora, S, Bachrach, L, Gilsanz (2003) “Noninvasive techniques for bone mass measurement” In: Glorieux, FH, Pettifor, JM, Jüppner, H (eds.), Pediatric bone Biology & diseases, Academic Press, San Diego, pp 303-324

    Chapter  Google Scholar 

  18. A Prentice TJ Parsons TJ Cole (1994) ArticleTitleUncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants Am J Clin Nutr 60 837–842 Occurrence Handle1:STN:280:DyaK2M%2Fns12hsA%3D%3D Occurrence Handle10.1093/ajcn/60.6.837

    Article  CAS  Google Scholar 

  19. E Stein E Shane (2003) ArticleTitleSecondary osteoporosis Endocrinol Metab Clin North Am 32 115–134 Occurrence Handle10.1016/S0889-8529(02)00062-2

    Article  Google Scholar 

  20. T Hantgartner (1990) ArticleTitleInfluence of fat on bone measurements with dual-energy absorptiometry Bone Miner 9 71–78 Occurrence Handle10.1016/0169-6009(90)90101-K

    Article  Google Scholar 

  21. WJ Fessel LB Hurley (2003) ArticleTitleIs HIV sequestered in bone? Possible implications of virological and immunological findings in some HIV-infected patients with bone disease AIDS 17 255–257 Occurrence Handle10.1097/00002030-200301240-00016

    Article  Google Scholar 

  22. A Viganò S Mora (2004) ArticleTitleAdverse effects of antiretroviral therapy: Focus on bone density Expert Opin Drug Saf 3 199–208 Occurrence Handle10.1517/14740338.3.3.199

    Article  Google Scholar 

  23. T Diamond B Depczynski (1996) ArticleTitleAcquired osteosclerosis associated with intravenous drug use and hepatitis C infection Bone 19 679–683 Occurrence Handle1:STN:280:DyaK2s7it1CitQ%3D%3D Occurrence Handle10.1016/S8756-3282(96)00304-3

    Article  CAS  Google Scholar 

  24. JL Shaker WR Reinus MP Whyte (1998) ArticleTitleHepatitis C-associated osteosclerosis: late onset after blood transfusion in an elderly woman J Clin Endocrinol Metab 83 93–98 Occurrence Handle1:CAS:528:DyaK1cXitVGjsg%3D%3D Occurrence Handle10.1210/jcem.83.1.4521

    Article  CAS  Google Scholar 

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Acknowledgments

The research in this article was supported by Grant No. 054 from Istituto Superiore di Sanità - V Programma Nazionale di Ricerca sull’AIDS - 2004.

Dr. Ilaria Zamproni is the recipient of a fellowship by Fondazione Carlo Erba, Milano, Italy.

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Authors and Affiliations

  1. Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Via Olgeltina 60, Milan, Italy

    S. Mora & I. Zamproni

  2. Chair of Pediatrics, L. Sacco Hospital, Via G.B. Grassi 74, Milan, Italy

    V. Giacomet, L. Cafarelli, C. Figini & A. Viganò

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  1. S. Mora
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  2. I. Zamproni
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  3. V. Giacomet
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  4. L. Cafarelli
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  5. C. Figini
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  6. A. Viganò
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Correspondence to S. Mora.

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Mora, S., Zamproni, I., Giacomet, V. et al. Analysis of Bone Mineral Content in Horizontally HIV-Infected Children Naïve to Antiretroviral Treatment. Calcif Tissue Int 76, 336–340 (2005). https://doi.org/10.1007/PL00020973

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