Abstract
Male 8-day-old mice that have part of chromosome 7 translocated to an X chromosome [T(X;7)1Ct] and that are chromosomally unbalanced for chromosome 7, and consequently trisomic for that part of chromosome 7, were found to have a smaller nucleosome repeat unit size than normal littermate males (Rake, A. V., and Edwards, R. H.,Biochem. Genet. 25:671, 1987). This smaller nucleosome size is maintained in adult trisomic males. Males with a balanced chromosomal translocation [T(X;7)1Ct] had a normal nucleosome size compared to their littermates. The nucleosome unit size is not altered in two other types of aneuploid mice studied (XO vs XX, 2n=39 and 40, respectively; and Ts1217 vs normal, 2n=40 and 41, respectively).
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Rake, A.V. Nucleosome unit repeat size in aneuploid mice. Biochem Genet 28, 389–397 (1990). https://doi.org/10.1007/PL00020662
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DOI: https://doi.org/10.1007/PL00020662