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Two sequence-specific binding proteins from the promoter region of thec-Ha-ras-I oncogene

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Abstract

The role of sequence-specific binding proteins in transcriptional control in higher eukaryotes is unclear. We have investigated the control region of thec-Ha-ras-I protooncogene containing upstream sequences from the transcriptional initiation point. Two proteins, which bind these sequences, with molecular weights of 20 K and 43 K were found. The possible role in the process of transformation is discussed.

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Authors and Affiliations

  1. Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    T. Dimitrov

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  1. T. Dimitrov
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I wish to thank Drs. D. A. Spandidos and N. M. Wilkie for their continuous support during my visit at the Beatson Institute for Cancer Research in Glasgow on an IAEA Fellowship.

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Dimitrov, T. Two sequence-specific binding proteins from the promoter region of thec-Ha-ras-I oncogene. Biochem Genet 27, 395–402 (1989). https://doi.org/10.1007/PL00020583

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  • DOI: https://doi.org/10.1007/PL00020583

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