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Glucose-6-phosphate dehydrogenase deficiency and sulfadimidin acetylation phenotypes in Egyptian oases

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Abstract

Screening of 1315 males from two Egyptian oases for glucose-6-phosphate dehydrogenase deficiency (G-6PD) found an incidence of 5.9%. The rate of acetylation of sulfadimidin was also studied, and a bimodal distribution was found with 73% rapid acetylators. There is a correlation between high frequency of G-6PD deficiency and high frequency of slow acetylation rate.

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References

  • Belsey, M. (1973). The epidemiology of Favism.Bull. WHO 481.

    Google Scholar 

  • Beutler, E. (1966). A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency and glutathione reductase deficiency.Blood 28553.

    Google Scholar 

  • Bottini, E., Lucarelli, P., Agostino, R., Palmarino, R., Businco, L., and Antognoni, G. (1971). Favism: Association with erythrocyte acid phosphatase phenotype.Science 171409.

    Google Scholar 

  • Bratton, A., and Marshall, E. (1939). A new coupling component for sulfanilamide determination.J. Biol. Chem. 128537.

    Google Scholar 

  • Brewer, G. (1986). Pharmacogenetic interaction glucose-6-phosphate dehydrogenase deficiency with acetylation and hydroxylation. In Yoshida, A., and Beutler, E. (eds.),Glucose-6-phosphate Dehydrogenase Academic Press, New York, pp. 13–23.

    Google Scholar 

  • Carson, P., Flanagan, C., Ickes, C., and Alving, A. (1956). Enzyme deficiency in primaquine sensitive erythrocytes.Science 124484.

    Google Scholar 

  • Cartwright, R. A., Ahmed, R. A., and Rogess, H. J. (1984). N-acetyltransferase phenotypes in Iraqui and British population.Hum. Hered. 34101.

    Google Scholar 

  • Dern, R., Beutler, E., and Alving, A. (1981). The hemolytic effect of primaquine.J. Lab. Clin. Med. 97751.

    Google Scholar 

  • Evans, D., Manley, K., and McKusick, V. (1960). Genetic control of isoniazid metabolism in man.Br. Med. J. 2185.

    Google Scholar 

  • Fessas, P., Doxiadis, S., and Valaes, T. (1962). Neonatal Jaundice in G-6PD deficient infants.Br. Med. J. 111359.

    Google Scholar 

  • Fiorelli, G., Finazzi, G., Manoussakis, C., Palomba, V., and Fenu, M. (1982). G-6PD deficiency in Sardinia: Genetic heterogeneity and clinical implications. In Weatherallet al. (eds.),Adv. Red Cell Biol. Raven Press, New York, pp. 399–408.

    Google Scholar 

  • Frymoyer, J., and Jacox, R. (1963). Investigation of the genetic control of sulfadiazine and isoniazid metabolism in the rabbit.J. Lab. Clin. Med. 62891.

    Google Scholar 

  • Hoo, J., Hussein, L., and Goedde, H. (1977). A simplified micromethod for the determination of the acetylator phenotype.J. Clin. Chem. Biochem. 15329.

    Google Scholar 

  • Hrdlicka, A. (1912). The natives of Kharga Oasis, Egypt.Smithson. Misc. Coll. 591.

    Google Scholar 

  • Karim, A. K., El-Fellah, M. S., and Evans, D. A. (1981). Human acetylator polymorphism: Estimate of allele frequency in Libya and details of global distribution.J. Med. Genet. 18325.

    Google Scholar 

  • Magon, A., Leipzig, R., Zannoni, V., and Brewer, G. (1981). Interactions of glucose-6-phosphate dehydrogenase deficiency with drug acetylation and hydroxylation reactions.J. Lab. Clin. Med. 97764.

    Google Scholar 

  • McCaffrey, R., Halsted, C., and Abdel Wahab, M. (1971). Chloramphenicol-induced hemolysis in Caucasian glucose-6-phosphate dehydrogenase deficiency.Ann. Intern. Med. 74722.

    Google Scholar 

  • McCaffrey, R., Farid, Z., and Kent, D. (1972). Acute hemolysis with Ambilhar treatment in glucose-6-phosphate dehydrogenase deficiency.Trans. Roy. Soc. Trop. Med. Hyg. 66795.

    Google Scholar 

  • McCurdy, P., Kamel, K., and Selim, O. (1974). Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt.J. Lab. Clin. Med. 84673.

    Google Scholar 

  • Motulsky, A. (1964). Hereditary red cell traits and malaria.Am. J. Trop. Med. 13147.

    Google Scholar 

  • Selim, O., Kamel, K., Azim, A., Gaballah, F., Sabry, F., Ibrahim, W., Moafy, N., and Hoerman, K. (1974). Genetic markers and anthropometry in the populations of the Egyptian Oases of El-Kharga and El-Dakhla.Hum. Hered. 24259.

    Google Scholar 

  • Stamatoyannopoulos, G., Fraser, G., Motulsky, A., Fessas, P. H., Akrivakis, A., and Papayanopoulou, T. H. (1966). On the familial predisposition to favism.Am. J. Hum. Genet. 18253.

    Google Scholar 

  • Weber, W., and Brenner, W. (1974). A filter paper method for determining isoniazid acetylator phenotype.Am. J. Hum. Genet. 26467.

    Google Scholar 

  • Weber, W., and Hein, D. W. (1985). N-Acetylation pharmacogenetics.Am. Soc. Pharm. Exp. Ther. 3725.

    Google Scholar 

  • Yoshida, A., and Beutler, E. (eds.) (1986).Glucose-6-phosphate Dehydrogenase Academic Press, New York.

    Google Scholar 

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This work was supported by a grant from the International Center of Agricultural Research in the Dry Areas (ICARDA), Nile Valley project of faba beans.

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Hussein, L., Yamamah, G. & Saleh, A. Glucose-6-phosphate dehydrogenase deficiency and sulfadimidin acetylation phenotypes in Egyptian oases. Biochem Genet 30, 113–121 (1992). https://doi.org/10.1007/PL00020423

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  • DOI: https://doi.org/10.1007/PL00020423

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