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Pharmacokinetics and effects after intravenous administration of high-dose boron to rat

  • Teruaki Tagawa
  • Koichi Kono
  • Tomotaro Dote
  • Kan Usuda
  • Hiroyuki Nishiura
  • Chisato Koizumi
  • Masahisa Saito
  • Hisangea Nakaya
  • Hidehiro Nagaie

Abstract

 Boron (B) compounds have been widely used in the chemical industry, agriculture, and environmental science. The kinetics and toxicity of B were studied by analyzing several serum and urine parameters after a single intravenous injection of sodium tetraborate solution (B: 85.7 mg/kg) in Wistar male rats. Blood samples were removed at 0, 1, 2, 4, and 6 h after injection. The serum parameters studied included: B, Na, Ca, K, P, Mg, γ-GTP, AST, ALT, BUN, Cr, CK, LDH and ALD. Plasma concentration-time profiles of B were evaluated by a nonlinear least-squares method for fitting data to polyexponential equations and calculation of relevant pharmacokinetic parameters. Urine samples were collected from the bladder following infusion. The urinary parameters that were studied included urine volume and excretion of B, Cr and NAG. Results indicated that a two-compartment model could describe the elimination of B from plasma after intravenous administration. Urine volume significantly increased. A diuretic effect of B was noted.

Key words Sodium tetraborate Intravenous administration Pharmacokinetics Polyuria 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Teruaki Tagawa
    • 1
  • Koichi Kono
    • 1
  • Tomotaro Dote
    • 1
  • Kan Usuda
    • 1
  • Hiroyuki Nishiura
    • 1
  • Chisato Koizumi
    • 1
  • Masahisa Saito
    • 1
  • Hisangea Nakaya
    • 1
  • Hidehiro Nagaie
    • 1
  1. 1.Department of Hygiene and Public Health, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka 569, Japan e-mail: hyg011@art.osaka-med.ac.jp Tel.: 0726-84-6419; Fax: 0726-84-6519JP

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