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Family and genetic studies on the relationship of schizophrenia to affective disorders

  • W. Maier
  • Marcella Rietschel
  • Dirk Lichtermann
  • Dieter B. Wildenauer

Abstract

Schizophrenia is a genetically influenced disease with a broad and heterogeneous phenotype transmitted in families. Of particular interest is the familial-genetic relationship between schizophrenia and affective disorders. Taking advantage of refined epidemiological methods, the dichotomy between both groups of disorders is not less consistently found than expected. Recently, linkage studies identified multiple candidate regions for susceptibility genes for each of both disorders. Several of these candidate regions for schizophrenia are overlapping with candidate regions for bipolar disorder. Thus, the hypothesis of an etiological dichotomy of schizophrenia and affective disorders faces a new challenge.

Key words Schizophrenia Affective disorders Family studies Obligate carriers Linkage studies 

Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • W. Maier
    • 1
  • Marcella Rietschel
  • Dirk Lichtermann
  • Dieter B. Wildenauer
    • 1
  1. 1.Klinik für Psychiatrie und Psychotherapie der Universität Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany e-mail: w.maier@uni-bonn.deDE

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