Abstract
The aim of this study was to evaluate serum advanced glycation end products (S-AGEs) in a group of adolescents and young adults with type 1 (insulin-dependent) diabetes mellitus and with diabetic microvascular complications (nephropathy or retinopathy). Fifty-two patients were included in the study (age range 14.2–28.8 years, onset of diabetes before the age of 12 years, duration of diabetes longer than 7 years); 45 patients without diabetic angiopathy and 63 healthy controls were also selected. S-AGEs were significantly increased in patients with diabetic angiopathy compared with controls (19.9±3.8 vs. 11.8±2.8 U/ml, P<0.001). Higher S-AGE levels were found in patients with severe diabetic nephropathy and retinopathy. When the albumin excretion rate (AER) was >100 µg/min per 1.73 m2, S-AGE levels were 23.1±2.4 U/ml; when the AER was 50–100 μg/min per 1.73 m2 levels were 19.8±1.9 U/ml, and for an AER of 20–50 μg/min per 1.73 m2 the corresponding value was 16.1±2.1 U/ml (P<0.005). Patients with proliferative retinopathy had S-AGE levels of 22.2±2.6 U/ml, those with preproliferative retinopathy 20.7±2.2 U/ml, and background retinopathy 17.6±1.9 U/ml (P<0.01). A significant correlation was found between levels of glycosylated hemoglobin (HbA1c) and S-AGE (r=0.43, P<0.01). S-AGE concentrations are markedly increased in type 1 diabetic adolescents and young adults with diabetic nephropathy and retinopathy. The severity of diabetic angiopathy is related to the serum levels of AGEs.
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Received: 22 April 1999 / Revised: 22 November 1999 / Accepted: 5 January 2000
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Chiarelli, F., Catino, M., Tumini, S. et al. Advanced glycation end products in adolescents and young adults with diabetic angiopathy. Pediatr Nephrol 14, 841–846 (2000). https://doi.org/10.1007/PL00013443
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DOI: https://doi.org/10.1007/PL00013443