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A specialized mitochondrial molecular chaperone system:¶A role in formation of Fe/S centers

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Abstract.

Mitochondria contain a specialized system of molecular chaperones that plays a critical role in the biogenesis of Fe/S centers. This Hsp70:J-protein system shows many similarities to the system found in bacteria, but the precise role of neither chaperone system has been defined. However, evidence to date suggests an interaction with the scaffold protein on which a transient Fe/S center is assembled, and thus implies a role in either assembly of the center or its transfer to recipient proteins.

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Authors and Affiliations

  1. Department of Biomolecular Chemistry, 1300 University Avenue, University of Wisconsin, Madison, Wisconsin 53706 (USA), Fax +1 608 262 5253; e-mail: ecraig@facstaff.wisc.edu, , , , , , US

    E. A. Craig

  2. Department of Molecular and Cellular Biology, Faculty of Biotechnology, University of Gdansk, 80-822 Gdansk, Kladki 24 (Poland), , , , , , PL

    J. Marszalek

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  1. E. A. Craig
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  2. J. Marszalek
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Craig, E., Marszalek, J. A specialized mitochondrial molecular chaperone system:¶A role in formation of Fe/S centers. CMLS, Cell. Mol. Life Sci. 59, 1658–1665 (2002). https://doi.org/10.1007/PL00012493

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  • DOI: https://doi.org/10.1007/PL00012493

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