Ovarian serous adenocarcinoma with anaplastic areas containing osteoclast-like multinucleated giant cells

Abstract

Ovarian tumors with osteoclast-like multinucleated giant cells are rarely encountered, and the existence of osteoclast-like giant cells in ovarian tumors may have no effect on the patients' prognosis. We report a patient with ovarian serous adenocarcinoma containing osteoclast-like multinucleated giant cells in the anaplastic areas of the tumor, who had a poor prognosis. A recurrent tumor showed the same anaplastic appearance as that of the primary tumor, with osteoclast-like giant cells. Forty-one percent of tumor cells were positive for MIB-1 (Ki-67) antigen, and many cells overexpressed p53 protein. However, the giant cells were negative for both antigens, which meant that they were non-cycling cells. The giant cells were also negative for epithelial and non-epithelial antigens. The multinucleated osteoclast-like giant cells, as well as mononucleated tumor cells around the giant cells, expressed p21 (WAF1/ClP1) protein. These findings suggest that the multinucleated osteoclast-like giant cells in this tumor originated from the p21-expressing mononuclear tumor cells. The coexistence of anaplastic foci with multinucleated giant cells in serous adenocarcinomas of the ovary may indicate a poor prognosis.

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Received: August 31, 1999 / Accepted: April 13, 2000

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Matsuta, M., Matsuta, M. & Kagabu, T. Ovarian serous adenocarcinoma with anaplastic areas containing osteoclast-like multinucleated giant cells. Int J Clin Oncol 5, 280–283 (2000). https://doi.org/10.1007/PL00012050

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  • Key words Osteoclast-like giant cells
  • Ovarian serous adenocarcinoma