Abstract.
Fifty patients with adenocarcinoma of the lung were enrolled in this study, including 20 patients with recurrence and 30 patients without recurrence 1 year after surgery. Serial serum levels of cytokeratin fragment 19 (CYFRA 21-1) and carcinoembryonic antigen (CEA) were measured before the operation and 1 week, 1 month, 3 months, 6 months, 9 months, and 12 months after surgery for the early detection of recurrence. The results revealed that the mean serum values of either CYFRA 21-1 or CEA were significantly higher until 9 and 12 months after surgery in the 20 patients with recurrent adenocarcinoma compared with the 30 patients without recurrent adenocarcinoma. We conclude that CYFRA 21-1 is not a better marker than CEA for early prediction of adenocarcinoma. We conclude that CYFRA 21-1 is not a better marker than CEA for early prediction of adenocarcinoma recurrence in lung.
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Accepted for publication: 7 July 1999
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Kao, CH., Hsieh, JF., Ho, YJ. et al. Cytokeratin Fragment 19 (CYFRA 21-1) and Carcinoembryonic Antigen for Early Prediction of Recurrence of Lung Adenocarcinoma. Lung 177, 333–337 (1999). https://doi.org/10.1007/PL00007651
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DOI: https://doi.org/10.1007/PL00007651