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Lung

, Volume 175 , Issue 4 , pp 213 –223 | Cite as

Pleural Sclerosis for the Treatment of Pneumothorax and Pleural Effusion

  • R. W.  Light
  • F. S.  Vargas

Abstract.

Pleural sclerosis is indicated to obliterate the pleural space when one wants to prevent the recurrence of a spontaneous pneumothorax or the reaccumulation of a pleural effusion. Although many different agents ranging from antibiotics to antiseptics to antineoplastics to talc have been advocated, none is ideal. It is interesting that in the era when we are mapping the human genome, the agent most commonly used for pleurodesis is talc. Talc is very inhomogeneous, and the mechanisms by which it produces pleurodesis are unknown. In this review we will discuss the theory and mechanism of pleurodesis, the indications and contraindications for it, the advantages and disadvantages of the agents presently used for it, and our recommendations for the procedure.

Key words: Pleurodesis—Pneumothorax—Pleural effusion—Talc—Tetracycline 

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Copyright information

© Springer-Verlag New York Inc. 1997

Authors and Affiliations

  • R. W.  Light
    • 1
  • F. S.  Vargas
    • 2
  1. 1.Pulmonary Disease Program, Saint Thomas Hospital, and Department of Medicine, Vanderbilt University, Nashville, Tennessee 37202, USAUS
  2. 2.Department of Medicine, University of Sao Paulo, Instituto do Coracao, Sao Paulo, BrazilBR

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