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Archives of Gynecology and Obstetrics

, Volume 266, Issue 1, pp 12–17 | Cite as

Plasma and follicular fluid concentrations of LHRH antagonist cetrorelix (Cetrotide®) in controlled ovarian stimulation for IVF

  • M. Ludwig
  • C. Albano
  • F. Olivennes
  • R. E. Felberbaum
  • J. Smitz
  • O. Ortmann
  • P. Romeis
  • G. Niebch
  • B. Pechstein
  • H. Riethmüller-Winzen
  • P. Devroey
  • K. Diedrich
Original Article

Abstract 

Cetrorelix was administered in differing daily dosages for controlled ovarian stimulation. The dosage levels were 3 mg (9 cycles), 1 mg (19 cycles), 0.5 mg (43 cycles), 0.25 mg (46 cycles) and 0.1 mg (7 cycles). In the 3 mg, 1 mg and 0.5 mg group the respective median plasma concentrations of cetrorelix on the day of oocyte pick-up (OPU) were 2.10 ng/ml, 1.42 ng/ml and 0.88 ng/ml and 1.03 ng/ml, 0.46 ng/ml and 0.49 ng/ml on the day of embryo transfer (ET). In the 0.25 mg and 0.1 mg groups plasma cetrorelix levels were below the limit of quantification. The cetrorelix concentrations in follicular fluid (FF) in the 0.25 mg group were detec- table in only 14 out of 44 samples, while in the 0.1 mg group no detectable concentrations could be obtained. We also examined 80 cycles after single doses of 5 mg (7 cycles), 3 mg (42 cycles), and 2 mg (31 cycles) cetro-relix. On the day of OPU the respective median plasma concentrations of cetrorelix were 0.57 ng/ml, 0.62 ng/ml, and 0.56 ng/ml, and 0.61 ng/ml and 0.28 ng/ml on the day of ET in the 5 mg and 3 mg groups. In the 2 mg group, the plasma concentrations fell to below limits of quantification in 8/9 samples on the day of ET. In 26 out of 27 FF samples cetrorelix was detectable in the 3 mg single dose group (median level: 0.69 ng/ml).

Keywords LHRH antagonist Controlled ovarian stimulation Plasma concentrations Follicular fluid Cetrorelix 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. Ludwig
    • 1
  • C. Albano
    • 2
  • F. Olivennes
    • 3
  • R. E. Felberbaum
    • 1
  • J. Smitz
    • 2
  • O. Ortmann
    • 1
  • P. Romeis
    • 4
  • G. Niebch
    • 4
  • B. Pechstein
    • 4
  • H. Riethmüller-Winzen
    • 4
  • P. Devroey
    • 2
  • K. Diedrich
    • 1
  1. 1.Department of Gynecology and Obstetrics, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany e-mail: Ludwig_M@t-online.de Tel.: ++49-451-5002133, ++49-451-5002134 Fax: ++49-451-5002139DE
  2. 2.Center of Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit Brussels, BelgiumBE
  3. 3.Hôpital Antoine Béclère, Clamart, FranceFR
  4. 4.ASTA Medica AG, Frankfurt, GermanyDE

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