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Recurrent pregnancy losses and the role of immunotherapy

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract 

Post implantation pregnancy losses are psychologically and economically stressful to the childbearing population. The etiology in the vast majority of cases is unknown but is partly thought to result from a breakdown of the maternal tolerance to the fetoplacental unit. Immunologically based therapy remains controversial but no alternative therapy is available at the moment. This article reviews the conceived immunological basis of recurrent pregnancy losses, discussing the controversies arising, and recommending the use of intravenous immunoglobulin, IVIg, in well controlled experiments for further clinical trials.

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Authors and Affiliations

  1. Department of Biochemistry, University of Nairobi, Kenya, , , , , , KE

    Charles A. Omwandho & Aloys G. Tumbo-Oeri

  2. Department of Obstetrics and Gynecology, Institute of Reproductive Medicine, Rosenhöhe Hospital, An der Rosenhöhe 27, D-33647 Bielefeld, Germany e-mail: Tinneberg@SK-BIELEFELD.DE Tel.: +49-521-943-8200/8201, Fax: +49-521-943-8299, , , , , , DE

    H. R. Tinneberg

  3. Biological Sciences Department, The University of Newcastle, Australia, , , , , , AU

    Timothy K. Roberts

  4. Discipline of Reproductive Medicine, The University of Newcastle, Australia, , , , , , AU

    John Falconer

Authors
  1. Charles A. Omwandho
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  2. H. R. Tinneberg
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  3. Aloys G. Tumbo-Oeri
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  4. Timothy K. Roberts
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  5. John Falconer
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Received: August 1999 / Accepted: 10 December 1999

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Omwandho, C., Tinneberg, H., Tumbo-Oeri, A. et al. Recurrent pregnancy losses and the role of immunotherapy. Arch Gynecol Obstet 264, 3–12 (2000). https://doi.org/10.1007/PL00007480

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  • DOI: https://doi.org/10.1007/PL00007480

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