Skip to main content
Log in

Evolution of a Mammalian Promoter Through Changes in Patterns of Transcription Factor Binding

  • Published:
Journal of Molecular Evolution Aims and scope Submit manuscript

An Erratum to this article was published on 01 February 1999

Abstract.

Previously, we identified evolutionarily derived changes in the pattern of nuclear factor binding to overlapping sites (termed A, B, and C, in proximal to distal order) within the promoter region of the murine D7Rp2e gene. In Mus domesticus, strong binding occurs at site B, with weak binding at sites A and C; in M. pahari, strong binding is observed at sites A and C, with weak binding at site B. The M. pahari-specific occupancy pattern is associated with repression of transcription. Presently, we have identified two interspecies changes, a single A → G substitution within site B and a 7-bp indel within site C, that are primary determinants of the interspecies differences. These mutations alter both the pattern of binding site occupancy and the ability to repress transcription. The results are discussed in terms of a model involving a dynamic equilibrium between states of binding site occupancy, the nature of which can be modified during evolution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 21 August 1997 / Accepted: 25 November 1997

An erratum to this article is available at http://dx.doi.org/10.1007/PL00006463.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, N., Berger, F. Evolution of a Mammalian Promoter Through Changes in Patterns of Transcription Factor Binding. J Mol Evol 46, 639–648 (1998). https://doi.org/10.1007/PL00006344

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/PL00006344

Navigation