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Persistence of Bone Collagen Cross-Links in Skeletons of the Nuraghi Population Living in Sardinia 1500–1200 B.C.

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Abstract.

Bone collagen has a specific molecular ultrastructure which can be proved by birefringence. This protein, forming the main organic component of bone tissue, is known to survive millennia in paleontological bones and teeth. Birefringence of bone collagen obtained from the skeletons of the Nuraghi population living in Sardinia c-ca 1500 years B.C. was found previously by the use of polarizing microscopy [1]. In this paper, using high pressure liquid chromatography (HPLC) techniques, we show the existence of bone collagen cross-links preserved in Nuraghi skeletons after more than 3000 years.

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Authors and Affiliations

  1. Department of Transplantology, Department of Dental Surgery, Medical University, Warsaw, Poland, , , , , , PL

    A. Wojtowicz

  2. Dental Research Centre, University of North Carolina, Chapel Hill, North Carolina, USA, , , , , , US

    M. Yamauchi

  3. Department of Biomedical Sciences, Division of Human Anatomy, University of Sassari, Italy, , , , , , IT

    A. Montella & P. Bandiera

  4. Department of Electron Microscopy, Medical University, Warsaw, Poland, , , , , , PL

    R. Sotowski

  5. Department of Histology and Embryology, Institute of Biostructure, Medical University, 02-004 Warsaw, Chalubinskiego 5, Poland, , , , , , PL

    K. Ostrowski

Authors
  1. A. Wojtowicz
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  2. M. Yamauchi
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  3. A. Montella
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  4. P. Bandiera
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  5. R. Sotowski
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  6. K. Ostrowski
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Received: 20 August 1997 / Accepted: 9 July 1998

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Wojtowicz, A., Yamauchi, M., Montella, A. et al. Persistence of Bone Collagen Cross-Links in Skeletons of the Nuraghi Population Living in Sardinia 1500–1200 B.C.. Calcif Tissue Int 64, 370–373 (1999). https://doi.org/10.1007/PL00005816

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  • DOI: https://doi.org/10.1007/PL00005816

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