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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 355, Issue 4, pp 545–549 | Cite as

Suppression of pentylenetetrazol-induced seizures by carnitine in mice

  • Zhengping Yu
  • Yoshihisa Iryo
  • Masato Matsuoka
  • H. Igisu
  • Masato Ikeda
Original article

Abstract

When ddY mice were pretreated with L-carnitine (5, 10 or 20mmol/kg), clonic as well as tonic seizures induced by pentylenetetrazol (PTZ) were dose-dependently suppressed. A time/response study (PTZ was injected 1, 5, 15 or 30min after L-carnitine) showed that the anticonvulsive effects were apparent when the interval between L-carnitine and PTZ administration was 15-30min. Saline containing 43% sucrose prolonged the latency to the first clonic seizure but was less effective than 20mmol/kg L-carnitine and did not suppress clonic or tonic seizures. Alterations in brain energy metabolites caused by PTZ including increase of lactate and decrease of ATP and phosphocreatine were also suppressed by L-carnitine. L-carnitine was more potent than D-carnitine in prolonging the latency to the first clonic seizure and in decreasing the frequency of clonic as well as tonic seizures. The anticonvulsive effects of L-carnitine in PTZ-induced seizures may be unrelated to the transport of long-chain acyl CoA since they were not interfered with by D-carnitine.

Key words Carnitine Seizures Pentylenetetrazol Cerebral protection Brain energy metabolism 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Zhengping Yu
    • 1
  • Yoshihisa Iryo
    • 1
  • Masato Matsuoka
    • 1
  • H. Igisu
    • 1
  • Masato Ikeda
    • 2
  1. 1.Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807, JapanJP
  2. 2.Department of Occupational Health Economics, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu 807, JapanJP

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