Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 2, pp 259–265 | Cite as

The pathogenesis of transmissible spongiform encephalopathy: routes to the brain and the erection of therapeutic barricades

  • P. Brown


Classical and modern studies of the pathogenesis of transmissible spongiform encephalopathy are reviewed, with particular attention paid to recent investigations of the routes of neuroinvasion. In various experimental models, a heirarchy of paths to the brain includes direct neural transit from the site of infection, replication in the spleen and neural entry through the spinal cord, and hematogenous spread. Possible modes and sites of therapeutic intervention are suggested.

Key words: Transmissible spongiform encephalopathy; Creutzfeldt-Jakob disease; scrapie; variant Creutzfeldt-Jakob disease; prion disease; follicular dendritic cells; B lymphocyte. 


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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • P. Brown
    • 1
  1. 1.Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Building 36, Room 4A-05, National Institutes of Health, 36 Convent Drive, MSC 4122, Bethesda (Maryland 20892-4122, USA), Fax + 1 301 496 8275, e-mail: US

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