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Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture

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Abstract.

A simple assay capable of evaluating the trophic effect of growth factors or active principles on human skin diploid fibroblasts in primary culture has been developed. The results indicate that at physiological concentrations (20–100 μg/ml) a human placental polydeoxyribonucleotide (PDRN) preparation enhances the growth of human skin diploid fibroblasts of the knee in primary culture. This effect is consistently reproducible in the case of patients over 60 years of age, and may explain previously reported data on the successful clinical applications of human placental preparations, suggesting a selective benefit of PDRN in wound healing when compared to other treatments.

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Authors and Affiliations

  1. Institute of Microbiology, University of Genoa, Largo Rosanna Benzi 10, I-16132 Genoa (Italy), Fax +39 10 50 4837, , , , , , IT

    O. Muratore, A. Pesce Schito, G. Cattarini, E. L. Tonoli, S. Gianoglio & G. C. Schito

  2. Chair of Orthopaedics and Traumatology, University of Genoa, Largo Rosanna Benzi 10, I-16132 Genoa (Italy), , , , , , IT

    S. Schiappacasse, L. Felli & F. Picchetta

Authors
  1. O. Muratore
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  2. A. Pesce Schito
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  3. G. Cattarini
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  4. E. L. Tonoli
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  5. S. Gianoglio
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  6. S. Schiappacasse
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  7. L. Felli
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  8. F. Picchetta
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  9. G. C. Schito
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Additional information

Received 24 October 1996; received after revision 11 December 1996; accepted 27 December 1996

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Muratore, O., Pesce Schito, A., Cattarini, G. et al. Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture. CMLS, Cell. mol. life sci. 53, 279–285 (1997). https://doi.org/10.1007/PL00000605

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  • DOI: https://doi.org/10.1007/PL00000605

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