Résumé
Objectifs: Déterminer la prévalence de l’Infection tuberculeuse reliée à un cas de tuberculose pulmonaire et laryngée et documenter les prédicteurs d’un PPD positif dans une entreprise.
Méthodes: Les contacts recensés ont subi l’épreuve de Mantoux (PPD) et ont répondu à un questionnaire.
Résultats: Des 112 travailleurs exposés, 92 (82,1%) ont été testés. Au seuil de 5 mm, 65,2% des travailleurs ont un PPD positif. En contrôlant le BCG antérieur et l’intensité de l’exposition, les résultats démontrent que l’âge est relié au PPD (RC: 3,5; IC 95%: 1,25–10,03). En contrôlant pour l’âge et le BCG, une exposition élevée est significative-ment reliée à la positrvité du PPD (RC: 5,6; IC95%: 1,25–24,68).
Conclusion: Le taux observé est probablement lié au fait que le cas-index était très contagieux, qu’il a eu des contacts dans un milieu fermé et durant une longue période avant d’être retiré du travail.
Abstract
Objectives: To determine the prevalence of tuberculosis infection related to a case of pulmonary and laryngeal tuberculosis in a workplace and to study PPD predictors.
Methods: The Mantoux skin test (PPD) was offered to all potentially infected contacts. Participants were asked to answer a questionnaire.
Results: Among 112 exposed employees, 92 (82.1%) were tested. At the 5 mm level, 65.2% of employees had positive tuberculin skin test (PPD). By controlling prior BCG and the degree of exposure, it showed a positive association between age and PPD (RC: 3.5; 95% CI: 1.25–10.03). When age and BCG were controlled, high exposure was statistically associated with PPD results (RC: 5.6; 95% CI: 1.25–24.68).
Conclusion: The observed prevalence rate is probably related to the fact that the index case was very infectious and had contact in an enclosed area over a long period of time before withdrawal from work.
Bibliographie
Comité sur l’immunisation du Québec (CIQ). Prévenir et enrayer…la tuberculose: Situation et recommandations. Québec: Gouvernement du Québec, Ministère de la Santé et des Services sociaux. Direction générale de la santé publique, 1996.
Frappier A, Cantin M, Davignon L, et al. BCG vaccination and pulmonary tuberculosis in Quebec. Can Med Assoc J 1971;105:707–10.
Ministère de la santé et des services sociaux. Tuberculose, Rapport Annuel–1992. Québec: Gouvernement du Québec, 1993.
Menzies R, Vissandjee B. Effect of Bacille Calmette-Guérin Vaccination on Tuberculin Reactivity. Am Rev Respir Dis 1992;145:621–25.
Jochem K, Tannenbaum TN, Menzies D. Prevalence of tuberculin skin test reactions among prison workers. Rev can santé publique 1997;88(3):202–6.
Menzies D, Fanning A, Yuan L, Fitzgerald M. Tuberculosis among health care workers. N Engl J Med 1995;332:92–98.
Centers for Disease Control. Nosocomial Transmission of Multidrug-Resistant Tuberculosis among HIV-infected Persons-Florida and New-York, 1988–1991. MMWR 1991;40:585–91.
Pearson ML, Jereb JA, Frieden TR, Crawford JT. Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis: A risk to patients and health care workers. Ann Intern Med 1992;117:191–96.
Beck-Sague C, Dooley SW, Hutton MD, et al. Hospital outbreak of multidrug-resistant Mycobacterium tuberculosis infections: Factors in transmission to staff and HIV-infected patients. JAMA 1992;268:1280–86.
Centers for Disease Control. Outbreak of multidrug-resistant tuberculosis at a hospital–New York City, 1991. MMWR 1993;42:427,433–34.
Centers for Disease Control. Probable transmission of multidrug-resistant tuberculosis in a correctional facility–California. MMWR 1993;42:48–51.
Centers for Disease Control. Tuberculosis transmission in a state correctional institution–California, 1990–1991. MMWR 1992;41:927–29.
Centers for Disease Control. Transmission of multidrug-resistant tuberculosis among immunocompromised persons in a correctional system–New York, 1991. MMWR 1992;41:507–10.
Poulin M, D’Halewyn MA, Remis R. Épidémie de mycobactéries atypiques dans un Centre hospitalier. Département de santé communautaire de l’Hôpital Ste-Marie. Trois-Rivières, 1989.
Menzies D. Issues in the management of contacts of patients with active pulmonary tuberculosis. Can J Public Health 1997;88(3):197–201.
Kenyon TA, Valway SE, Ihle WW, et al. Transmission of multidrug-resistant Mycobacterium tuberculosis during a long airplane flight. N Engl J Med 1996;334(15):933–38.
Alios BM, Gensheimer KF, Bloch AB, et al. Management of an outbreak of tuberculosis in a small community. Ann Intern Med 1996;125(2):114–17.
Nolan CH, Elarth AM, Barr H, et al. An outbreak of tuberculosis in a shelter for homeless men. Am Rev Respir Dis 1991;143:257–61.
Demeter S, Fanning A, MacDonald F. Contact tracing and follow-up of a case of laryngeal tuber-culosis–Alberta. Can Commun Dis Rep 1995;21(2):12–13.
Colditz GA, Brewer TF, Berkey CS, et al. Efficacy of BCG vaccine in the prevention of tuberculosis: Meta-analysis of the published literature. JAMA 1994;271:698–702.
Le Comité des normes (Tuberculose) de la Société de thoracologie du Canada. Normes canadiennes de traitement de la tuberculose. Quatrième édition, produit pour l’Association pulmonaire du Canada, 1996.
Adhikari N, Menzies R. Community-based tuberculin screening in Montreal: A cost-outcome description. Am J Public Health 1995;85(6):786–90.
Herrick TA, Davison ZM. School contact tracing for tuberculosis using two-step Mantoux testing. Rev can santé publique 1995;86(5):321–24.
Menzies R, Vissandjee B, Rocher I, St-Germain Y. The booster effect in two-step tuberculin testing among young adults in Montreal. Ann Intern Med 1994;120(3):190–98.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Drolet, MJ., Boisvert, R., Déry, S. et al. Enquête épidémiologique sur un cas de tuberculose dans une grande entreprise manufacturière québécoise. Can J Public Health 90, 156–159 (1999). https://doi.org/10.1007/BF03404497
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03404497