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Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides

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Abstract

Insulin-like growth factor-1 (IGF-1) is a multipotent growth factor involved in the growth, development and regulation of homeostasis in a tissue-specific manner. Alternative splicing, multiple transcription initiation sites and different polyadelynation signals give rise to diverse mRNA isoforms, such as IGF-1Ea, IGF-1Eb and IGF-1Ec transcripts. There is increasing interest in the expression of the IGF-1 isoforms and their potential distinct biological role. IGF-1Ec results from alternative splicing of exons 4-5-6 and its expression is upregulated in various conditions and pathologies. Recent studies have shown that IGF-1Ec is preferentially increased after injury in skeletal muscle during post-infarctal myocardium remodelling and in cancer tissues and cell lines. A synthetic analogue corresponding to the last 24 aa of the E domain of the IGF-1Ec isoform has been used to elucidate its potential biological role. The aim of the present review is to describe and discuss the putative bioactivity of the E domain of the IGF-1Ec isoform.

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  1. Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, 75 Micras Asias Str., 11527, Goudi-Athens, Greece

    George Vassilakos, Anastassios Philippou, Panagiotis Tsakiroglou & Michael Koutsilieris MD, PhD

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  1. George Vassilakos
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  2. Anastassios Philippou
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Vassilakos, G., Philippou, A., Tsakiroglou, P. et al. Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides. Hormones 13, 182–196 (2014). https://doi.org/10.1007/BF03401333

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