The Psychological Record

, Volume 40, Issue 3, pp 385–395 | Cite as

Behavioral Effects of Fluprazine in Lactating Hamsters and in Their Progeny

  • Diana L. Mendoza
  • Ricardo Mondragón
  • Lilian Mayagoitia
  • Cristina B. Randall


The spontaneous behavior of dams and pups was observed during lactation period, following daily i.p. administration of fluprazine (8 mg/kg/day) to females after parturition. Ethological techniques were applied, scanning every 30 min through 8 hr per day. Chronic treatment with fluprazine hydrochloride (DU 27716) to lactating hamsters, decreased nest building and self-grooming, disrupted pup retrieval, and increased infanticide. Other behaviors, such as nursing, exploration, attention, and ingestion were not altered indicating lack of sedative effects. Pups from fluprazine-treated mothers showed a decrease in the activity level, as well as lower mean weight than control infants. This suggests an interference on the mother-infant interactions, and/or fluprazine effects by drug or metabolites transfer via breast milk. Some sensorial (olfactory interference) and emotional (stress and fear) factors are considered as possible mechanisms for the behavioral action of fluprazine.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. BALK, M. W., & SLATER, G. M. (1987). Care and management. In G. L. Van Hoosier, Jr. & C. W. McPherson (Eds.), Laboratory hamsters (pp. 61–67). New York: Academic Press.Google Scholar
  2. BENTON, D., BRAIN, P. F., JONES, S., COLEBROOK, E., & GRIMM, V. (1983). Behavioral examinations of the anti-aggressive drug fluprazine. Behavioral Brain Research, 10, 325–338.CrossRefGoogle Scholar
  3. BIVIN, W. S., OLSEN, G. H., & MURRAY, K. A. (1987). Morphophysiology. In G. L. Van Hoosier, Jr. & C. W. McPherson (Eds.), Laboratory hamsters (pp. 9–36). New York: Academic Press.Google Scholar
  4. FLANNELLY, K. J., LIM, H. L., DIAMOND, M., BLANCHARD, D. C, & BLANCHARD, R. J. (1985). Fluprazine hydrochloride decreases copulation in male rats. Pharmocology, Biochemistry & Behavior, 22, 1–4.CrossRefGoogle Scholar
  5. FLEISHAKER, J. C, & MCNAMARA, P. J. (1988). In vivo evaluation in the lactating rabbit for a model of xenobiotic distribution into breast milk. Journal of Pharmacology and Experimental Therapeutics, 244, 919–924.PubMedGoogle Scholar
  6. FLOODY, O. R., & PFAFF, D. W. (1977). Aggressive behavior in female hamsters: The hormonal basis for fluctuations in female aggressiveness correlated with estrous state. Journal of Comparative and Physiological Psychology, 91, 443–464.CrossRefPubMedGoogle Scholar
  7. GIORDANO, A. L, SIEGEL, H. I., & ROSENBLATT, J. S. (1985). Intrasexual aggression during pregnancy and the estrous cycle in golden hamsters (Mesocricetus auratus). Aggressive Behavior, 12, 213–222.CrossRefGoogle Scholar
  8. HOFER, M. A. (1987). Early social relationships: A psychobiologist’s view. Child Development, 58, 633–647.CrossRefPubMedGoogle Scholar
  9. HUCK, U. W., LISK, R. D., & MCKAY, M. V. (1988). Social dominance and reproductive success in pregnant and lactating golden hamsters (Mesocricetus auratus) under seminatural conditions. Physiology and Behavior, 44, 313–319.CrossRefPubMedGoogle Scholar
  10. KEMBLE, E. D., & SCHULTZ, L. A. (1989). Effects of fluprazine hydrochloride on maternal behavior in mice. Behavioural Processes, 18, 61–69.CrossRefPubMedGoogle Scholar
  11. KEMBLE, E. D., SCHULTZ, L. A., & THORNTON, A. E. (1986). Effects of fluprazine hydrochloride on conspecific odor preferences in rats. Physiology and Behavior, 37, 53–56.CrossRefPubMedGoogle Scholar
  12. KEMBLE, E. D., THORNTON, A. E., & SCHULTZ, L A. (1987). Some fear potentiating effects of Fluprazine Hydrochloride in mice. Aggressive Behavior, 13, 269–280.CrossRefGoogle Scholar
  13. MAYAGOITIA, L, MONDRAGÓN, R., & LÓPEZ-LUJÁN, A. (1988). Diazepan effects in mice social behavior. Internation al Journal of Neuroscience, 41, 332–333.Google Scholar
  14. MEEK, L R., GIBSON, B. M., & KEMBLE, E. D. (1989). Effects of fluprazine hydrochloride on reactivity to a nonconspecific intruder. The Psychological Record, 39, 203–209.CrossRefGoogle Scholar
  15. MENDOZA, D. L, & MARTIN RAMIREZ, J. (1987). Play in kittens (Felis domesticus) and its association with cohesion and aggression. Bulletin of the Psychonomic Society, 25, 27–30.CrossRefGoogle Scholar
  16. MONTGOMERY-ST. L, T., FULLENKAMP, A. M., & FISCHER, R. B. (1988). A role for the hamster’s flank gland in heterosexual communication. Physiology & Behavior, 44, 759–762.CrossRefGoogle Scholar
  17. MURILLO, J. R., MENDOZA, D. L, & DIAZ, J. L. (1988). Behavioral effects of scopolamine in cats. International Journal of Neuroscience, 41, 223–230.CrossRefPubMedPubMedCentralGoogle Scholar
  18. MYERS, M. M., BRUNELLI, S. A., SHAIR, H. N., SQUIRE, J. M., & HOFER, M. A. (1989). Relationships between maternal behavior of Shr and Wky dams and adult blood pressures of cross-fostered F1 pups. Developmental Psychobiology, 22, 55–67.CrossRefPubMedPubMedCentralGoogle Scholar
  19. NUMAN, M. (1988). Maternal behavior. In E. Knobil & J. Neill, et al. (Eds.), The physiology of reproduction (pp. 1569–1645). New York: Raven Press.Google Scholar
  20. Olivier, B., & Mos, J. (1986). Serenics and aggression. Stress Medicine, 2, 197–209.CrossRefGoogle Scholar
  21. OLIVIER, B., MOS, J., & VAN OORSCHOT, R. (1985). Maternal aggression in rats: Effects of chlordiazepoxide and fluprazine. Psychoparmacology, 86, 68–76.CrossRefGoogle Scholar
  22. OLIVIER, B., VAN AKEN, H., JAARSMA, I., VAN OORSCHOT, R., ZETHOF, T., & BRADFORD, D. (1984) Behavioral effects of psychoactive drugs on agonistic behavior of male territorial rats (resident-intruder model). In K. A. Miczek, M. R. Kruk, & B. Olivier (Eds.), Ethopharmacological aggression research (pp. 137–156). New York: Alan R. Liss.Google Scholar
  23. OLIVIER, B., VAN DALEN, D. A. (1982). Social behavior in rats and mice: An ethologically based model for differentiating psychoactive drugs. Aggressive Behavior, 8, 163–168.CrossRefGoogle Scholar
  24. RACINE, M. A., & FLANNELLY, K. J. (1986). The offensive nature of maternal aggression in mice: Effects of fluprazine hydrochloride. Aggressive Behavior, 12, 417–424.CrossRefGoogle Scholar
  25. RACINE, M. A., FLANNELLY, K. J., & BLANCHARD, D. C. (1984). Anti-aggressive effects of Du 27716 on attack and defensive behaviors in male mice. In K. J. Flannelly, R. J. Blanchard, & D. C. Blanchard, (Eds.), Biological perspectives on aggression (pp. 281–293). New York: Alan R. Liss.Google Scholar
  26. REASNER, D. S., & JOHNSTON, R. E. (1988). Acceleration of reproductive development in female Djungarian hamsters by adult males. Physiology & Behavior, 43, 57–64.CrossRefGoogle Scholar
  27. RUSSELL, R. W. (1987). Drugs as tools for research in neuropsychology: A historical perspective. Neuropsychobiology, 18, 134–143.CrossRefPubMedGoogle Scholar
  28. SCHANBERG, S. M., & FIELD, T. M. (1987). Sensory deprivation stress and supplemental stimulation in the rat pup and preterm human neonate. Child Development, 58, 1431–1447.CrossRefPubMedGoogle Scholar
  29. SCHULTZ, L. A., & KEMBLE, E. D. (1986). Prey-dependent effects of fluprazine hydrochloride on predatory aggression in northern grasshopper mice (Onychomys leucogaster) and rats (Rattus norvegicus). Aggressive Behavior, 12, 267–275.CrossRefGoogle Scholar
  30. SELSETH, K. J., & KEMBLE, E. D. (1988). Fluprazine hydrochloride decreases play behavior but not social grooming in juvenile male rats. Bulletin of the Psychonomic Society, 26, 563–564.CrossRefGoogle Scholar
  31. SIEGEL, H. I., GIORDANO, A. L., MALLAFREM, C. M., & ROSENBLATT, J. S. (1983). Maternal aggression in hamsters: effects of stage of lactation, presence of pups, and repeated testing. New York: Academic Press.Google Scholar
  32. STANTON, M. R., GUTIERREZ, Y. R., & LEVINE, S. (1988). Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats. Behavioral Neuroscience, 102(5), 692–700.CrossRefPubMedGoogle Scholar
  33. SVARE, B., & MANN, M. A. (1983). Hormonal influences on maternal aggression. In B. B. Svare (Ed.), Hormonal and aggressive behavior (pp. 91–104). New York: Plenum Press.CrossRefGoogle Scholar
  34. THORNTON, A. E., & KEMBLE, E. D. (1986). Effects of fluprazine hydrochloride on an olfactory discrimination in rats. Bulletin of Psychonomic Society, 24(6), 456–458.CrossRefGoogle Scholar
  35. TURPIN, B., JOHNSTON, T. D., & FULK, K. R. (1988). Sibling inhibition of hoarding in post-weaning hamster pups (Mesocricetus auratus). Developmental Psychobiology, 21, 467–476.CrossRefPubMedGoogle Scholar
  36. VALZELLI, L. (1981). Psychobiology of aggression and violence. New York: Raven Press.Google Scholar
  37. VANDERBERGH, J. G. (1977). Reproductive coordination in the Golden hamster: Female influences on the male. Hormones and Behavior, 9, 264–275.CrossRefGoogle Scholar
  38. VAN DER POEL, A. M., OLIVIER, B., MOS. J., KRUK, M. R., MEELIS, W., & VAN AKEN, J. H. M. (1982). Anti-aggressive effect of a new phenylpiperazine compound (Du27716) on hypothalamically induced behavioural activities. Pharmacology, Biochemistry and Behavior, 17, 147–153.CrossRefPubMedGoogle Scholar
  39. WAGNER, S., SCHMIDT, W. J., & CHRET, G. (1988). Haloperidol and apomorphine-induced changes in pup searching behavior of house mice. Psychopharmacology, 95, 271–275.Google Scholar
  40. WILLIAMS, J. L. (1984). Influence of postpartum shock controllability on subsequent maternal behavior in rats. Animal Learning & Behavior, 12, 209–216.CrossRefGoogle Scholar

Copyright information

© Association of Behavior Analysis International 1990

Authors and Affiliations

  • Diana L. Mendoza
    • 1
  • Ricardo Mondragón
    • 2
  • Lilian Mayagoitia
    • 2
  • Cristina B. Randall
    • 1
  1. 1.Department of PsychobiologyUniversity of SevilleSevilleSpain
  2. 2.Mexican Institute of PsychiatryMexico

Personalised recommendations