Abstract
In conditioned taste aversion (CTA), a taste, the conditioned stimulus (CS), is paired with an illness-inducing stimulus, the unconditioned stimulus (US), to produce CS-US associations at very long (hours) intervals, a result that appears to violate the law of contiguity. The specific length of the maximum effective trace interval that has been reported differs from laboratory to laboratory. Metabolic rate may be a factor that influences the effective CS-US interval. Given that prior handling has been demonstrated to decrease stress and presumably lower metabolism, we examined the effect of handling on the effective CS-US intervals of 0, 90, and 180 min. Results indicated that handling rats for 1 min daily, for 21 days, may have extended the effective CS-US interval to 90 min in contrast to rats that were not handled. This finding indicates that subtle procedural differences may help explain the variability reported for the effective CS-US interval in various CTA studies.
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References
ADER, R. (2003). Conditioned immunomodulation: Research needs and directions. Brain, behavior, and Immunity, 17, 51–57. doi:10.1016/S0889-1591(02)00067-3
ANDERSON, M. J., HINDERLITER, C. F., & MISANIN, J. R. (2006). The effects of chronic water deprivation on metabolic rate and long-trace taste-aversion conditioning in rats. Neurobiology of Learning and Memory, 85, 199–205. doi:10.1016/j.nlm.2005.10.004
ARCHER, T., SJÖDÉN, P. O., NILSSON, L. G., & CARTER, N. (1979). Role of exteroceptive background context in taste-aversion conditioning and extinction. Animal Learning and Behavior, 7, 17–22.
DAVIS, J. E. (1937). The effect of advancing age on oxygen consumption of rats. American Journal of Physiology, 119, 28–33.
DOMJAN, M. (2005). Pavlovian conditioning: A functional perspective. Annual Review of Psychology, 56, 179–206.
ETSCORN, F., & STEPHENS, R. (1973). Establishment of conditioned taste aversions with a 24-hour CS-US interval. Physiological Psychology, 1, 251–253.
GARCIA, J., KIMELDORF, D. J., & KOELLING, R. A. (1955). A conditioned aversion towards saccharin resulting from exposure to gamma radiation. Science, 122, 157–158. doi:10.1126/science.122.3179.1089
GREEN, L., & RACHLIN, H. (1976). Learned taste aversions in rats as a function of delay, speed, and duration of rotation. Learning and Motivation, 7, 283–289. doi:10.1016/0023-9690(76)90035-7
HINDERLITER, C. F., GOODHART, M., ANDERSON, M. J., & MISANIN, J. R. (2002). Extended lowered body temperature increases the effective CS-US interval in conditioned taste aversion for adult rats. Psychological Reports, 90, 800–802. doi:10.2466/PR0.90.3.800-802
HINDERLITER, C. F., MUSCI, J. A., POLLACK, C. A., MISANIN, J. R., & ANDERSON, M. J. (2004). Hypothermia modifies the effective CS-US interval in conditioned taste aversion in rats. Neuroscience Letters, 369, 142–144.
HOLSON, R. R., SCALLET, A. C., ALI, S. F., & TURNER, B. B. (1991). “Isolation stress” revisited: Isolation-rearing effects depend on animal care methods. Physiology and Behavior, 49, 1107–1118. doi:10.1016/0031-9384(91)90338-O
KLEIBER, M., SMITH, A. H., & CHERNIKOFF, T. N. (1956). Metabolic rate of female rats as a function of age and body size. American Journal of Physiology, 159, 9–12.
MISANIN, J. R., ANDERSON, M. J., CHRISTIANSON, J. P., COLLINS, M. M., GOODHART, M. G., RUSHANAN, S. G., & HINDERLITER, C. F. (2002). Low body temperature, time dilation, and long-trace conditioned flavor aversion in rats. Neurobiology of Learning and Memory, 78, 167–177. doi:10.1006/nlme.2001.4048
MISANIN, J. R., CHRISTIANSON, J. P., ANDERSON, M. J., GIOVANNI, L. M., & HINDERLITER, C. F. (2004). Ketaset-Rompun extends the effective interstimulus interval in long-trace taste-aversion conditioning in rats. Behavioural Processes, 65, 111–121. doi:10.1016/j.beproc.2003.09.001
MISANIN, J. R., COLLINS, M., RUSHANAN, S., ANDERSON, M. J., GOODHART, M., & HINDERLITER, C. F. (2002). Aging facilitates long-trace taste-aversion conditioning in rats. Physiology and Behavior, 75, 759–764. doi:10.1016/S0031-9384(02)00671-6
MISANIN, J. R., GOODHART, M. G., ANDERSON, M. J., & HINDERLITER, C. F. (2002). The interaction of age and unconditioned stimulus intensity on long-trace conditioned flavor aversion in rats. Developmental Psychobiology, 40, 131–137. doi:10.1002/dev.10018
MISANIN, J. R., GRIEDER, D. L., & HINDERLITER, C. F. (1988). Age differences in the outcome of long-delay taste-aversion conditioning in rats. Bulletin of the Psychonomic Society, 26, 258–260.
MISANIN, J. R., KAUFHOLD, S. E., PAUL, R. L., HINDERLITER, C. F., & ANDERSON, M. J. (2006). A time contraction effect of acute tail-pinch stress on the associative learning of rats. Behavioural Processes, 71, 16–20. doi:10.1016/j.beproc.2005.09.001
MISANIN, J. R., WILSON, H. A., SCHWARZ, P. R., TUSCHAK, J. B., & HINDERLITER, C. F. (1998). Low body temperature affects associative processes in long-trace conditioned flavor aversion. Physiology and Behavior, 65(3), 581–590. doi:10.1016/S0031-9384(98)00212-1
ROLL, D. L., & SMITH, J. C. (1972). Conditioned taste aversion in anesthetized rats. In M. E. P. Seligman & J. Hager (Eds.), Biological boundaries of learning (pp. 98–102). New York: Appleton-Century-Crofts.
ROZIN, P., & REE, P. (1972). Long extension of the effective CS-US interval by anesthesia between CS and US. Journal of Comparative and Physiological Psychology, 80, 43–48. doi:10.1037/h0032831
SMITH, J. C., & ROLL, D. L. (1967). Trace conditioning with X-rays as an aversive stimulus. Animal Learning and Behavior, 9, 11–12.
VALLIERE, W., PETERSON, C. S., MISANIN, J. R., & HINDERLITER, C. F. (1985). Age differences in odor preference following an odor-illness pairing. Bulletin of the Psychonomic Society, 23, 427–429.
WATSON, J. B., & RAYNER, R. (1920). Conditioned emotional reactions. Journal of Experimental Psychology, 3, 1–4. doi:10.1037/h0069608
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This research was supported in part by a faculty scholarship grant from the University of Pittsburgh at Johnstown awarded to the first author.
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Hinderliter, C.F., Andrews, A. & Misanin, J.R. The Influence of Prior Handling on the Effective CS-US Interval in Long-Trace Taste-Aversion Conditioning in Rats. Psychol Rec 62, 91–96 (2012). https://doi.org/10.1007/BF03395789
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DOI: https://doi.org/10.1007/BF03395789