Abstract
The effects of neonatal experience can be influenced by treatment with chlorpromazine or reserpine. CPZ mitigated the effects of extra stimulation (mechanical rotation) procedures but had no effect upon non-stimulated neonates. High dosage levels of reserpine interacted with extra stimulation effects to produce neonatal mortality. Reserpine in lower dosage levels resulted in increased activity and defecation scores in both stimulated and non-stimulated Ss. Neither CPZ or reserpine affected the Ss’ responses to pressure stimulation of reflexogenous zones. Both drugs slowed the neonates’ response to “righting” themselves after being placed on their backs.
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CARMICHAEL, L. & SMITH, M. F. Quantified pressure stimulation and the specificity and generality of response in fetal life. J. gen. Psychol., 1939, 54, 425–434.
DENNENBERG, V. H. The effects of early experience. In E. S. E. Hafez (Ed.), The behavior of domestic animals. London, England: Bailliere, Tindall & Cox, 1962. Pp. 109–138.
EDWARDS, A. Experimental design in psychological research. (Rev. ed.), New York: Rinehart, 1960.
FULLER, J. L., CLARK, L. D. & WALLER, M. B. Effects of chlorpromazine upon psychological development in the puppy. Psychopharmacologia, 1960, 1, 393–407.
HARRIS, G. W. & LEVINE, S. Sexual differentiation of the brain and its experimental control. J. Physiol., 1962, 163, 42–43.
HESS, E. H. Effects of meprobamate on imprinting in waterfowl. Ann. N.Y. Acad. Sci., 1957, 67, 724–733.
JAILER, J. The maturation of the pituitary-adrenal axis in the newborn rat. Endocrinology, 1950, 46, 420–425.
KOVACH, J. Effects of autonomic drugs on imprinting. J. comp physiol. Psychol., 1964, 57, 183–187.
LEVINE, S. The effects of infantile experience on adult behavior. In A. J. Bachrach (Ed.), Experimental foundations of clinical psychology. New York: Basic Books, 1962. Pp. 139–169.
PHOENIX, C. H., GOY, R. W., GERALL, A. A. & YOUNG, W. C. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology, 1959, 65, 369–382.
ROSVOLD, H. E. & MIRSKY, A. F. The closed-field intelligence test for rats adapted for water-escape motivation. Canad. J.Psychol., 1954, 8, 10–16
SAWREY, J. M. & SAWREY, W. L. Ulcer production with reserpine and conflict. J. comp. physiol. Psychol., 1964, 57, 307–309.
WESTERMANN, E. O., MAICKEL, R. P. & BRODIE, B. B. On the mechanism of pituitary-adrenal stimulation by reserpine. J. Pharm. exp. Therap., 1962, 138, 208–217.
WOOLLEY, D. W. The biochemical bases of psychoses. New York: Wiley, 1962. Pp. 162–164.
YOUNG, R. D. Drug administration to neonatal rats: effects on later emotionality and learning. Science, 1964, 143, 1055–1057.
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This research was supported by Public Health Service Grant MH 08543 from the National Institute of Mental Health. I would like to thank Dr. Joachim Anschel, Warner Lamberth Research Institute, Morrisplains, N.J., for supplying the reserpine and placebo solutions used in this study.
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Young, R.D. Effect of Tranquilization of Neonatal Rats on Later Behavior. Psychol Rec 15, 401–407 (1965). https://doi.org/10.1007/BF03393606
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DOI: https://doi.org/10.1007/BF03393606