Skip to main content
Log in

Effect of Tranquilization of Neonatal Rats on Later Behavior

  • Published:
The Psychological Record Aims and scope Submit manuscript

Abstract

The effects of neonatal experience can be influenced by treatment with chlorpromazine or reserpine. CPZ mitigated the effects of extra stimulation (mechanical rotation) procedures but had no effect upon non-stimulated neonates. High dosage levels of reserpine interacted with extra stimulation effects to produce neonatal mortality. Reserpine in lower dosage levels resulted in increased activity and defecation scores in both stimulated and non-stimulated Ss. Neither CPZ or reserpine affected the Ss’ responses to pressure stimulation of reflexogenous zones. Both drugs slowed the neonates’ response to “righting” themselves after being placed on their backs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • CARMICHAEL, L. & SMITH, M. F. Quantified pressure stimulation and the specificity and generality of response in fetal life. J. gen. Psychol., 1939, 54, 425–434.

    Google Scholar 

  • DENNENBERG, V. H. The effects of early experience. In E. S. E. Hafez (Ed.), The behavior of domestic animals. London, England: Bailliere, Tindall & Cox, 1962. Pp. 109–138.

    Google Scholar 

  • EDWARDS, A. Experimental design in psychological research. (Rev. ed.), New York: Rinehart, 1960.

    Google Scholar 

  • FULLER, J. L., CLARK, L. D. & WALLER, M. B. Effects of chlorpromazine upon psychological development in the puppy. Psychopharmacologia, 1960, 1, 393–407.

    Article  PubMed  Google Scholar 

  • HARRIS, G. W. & LEVINE, S. Sexual differentiation of the brain and its experimental control. J. Physiol., 1962, 163, 42–43.

    Google Scholar 

  • HESS, E. H. Effects of meprobamate on imprinting in waterfowl. Ann. N.Y. Acad. Sci., 1957, 67, 724–733.

    Article  PubMed  Google Scholar 

  • JAILER, J. The maturation of the pituitary-adrenal axis in the newborn rat. Endocrinology, 1950, 46, 420–425.

    Article  PubMed  Google Scholar 

  • KOVACH, J. Effects of autonomic drugs on imprinting. J. comp physiol. Psychol., 1964, 57, 183–187.

    Article  PubMed  Google Scholar 

  • LEVINE, S. The effects of infantile experience on adult behavior. In A. J. Bachrach (Ed.), Experimental foundations of clinical psychology. New York: Basic Books, 1962. Pp. 139–169.

    Google Scholar 

  • PHOENIX, C. H., GOY, R. W., GERALL, A. A. & YOUNG, W. C. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology, 1959, 65, 369–382.

    Article  PubMed  Google Scholar 

  • ROSVOLD, H. E. & MIRSKY, A. F. The closed-field intelligence test for rats adapted for water-escape motivation. Canad. J.Psychol., 1954, 8, 10–16

    Article  PubMed  Google Scholar 

  • SAWREY, J. M. & SAWREY, W. L. Ulcer production with reserpine and conflict. J. comp. physiol. Psychol., 1964, 57, 307–309.

    Article  PubMed  Google Scholar 

  • WESTERMANN, E. O., MAICKEL, R. P. & BRODIE, B. B. On the mechanism of pituitary-adrenal stimulation by reserpine. J. Pharm. exp. Therap., 1962, 138, 208–217.

    Google Scholar 

  • WOOLLEY, D. W. The biochemical bases of psychoses. New York: Wiley, 1962. Pp. 162–164.

    Google Scholar 

  • YOUNG, R. D. Drug administration to neonatal rats: effects on later emotionality and learning. Science, 1964, 143, 1055–1057.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This research was supported by Public Health Service Grant MH 08543 from the National Institute of Mental Health. I would like to thank Dr. Joachim Anschel, Warner Lamberth Research Institute, Morrisplains, N.J., for supplying the reserpine and placebo solutions used in this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Young, R.D. Effect of Tranquilization of Neonatal Rats on Later Behavior. Psychol Rec 15, 401–407 (1965). https://doi.org/10.1007/BF03393606

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03393606

Navigation