Abstract
Epilepsy is a chronic noncommunicable disorder of the brain that affects people of all ages. Around 50 million people worldwide have epilepsy (WHO, 2012). 45,000 children under the age of 15, develop epilepsy each year (Epilepsy Foundation, 2010). Lower income was, however, associated with a higher incidence of epilepsy in all ethnic groups (Benn, et al., 2008). Neuropsychological impairment is an important co-morbidity of chronic epilepsy (Elger et al., 2004). Recent investigations have focused on the cumulative neurobiological burden associated with epilepsy and the risk of progressive cognitive impairment, but none have studied the effect of epilepsy on cognition on the developing brain, from India so far. Hence, the aim of the study was to study the effect of the temporal and extra temporal epilepsy on the cognitive functioning of children aged 7–12 years. Methodology: a cross-sectional study was carried out with a sample of 52 consenting children with an history of seizure (the 1st seizure occurred at least three months back i.e. the problem of seizure disorder was at least three months old) of neuropsychological assessment of epilepsy were administered with standardized neuropsychological tests, namely (Gesell’s Drawing Test- by Verma et al., 1972, PGI-Memory Scale for children- by Kohli et al., 1998) Results indicated significant findings in nine areas of neuropsychological functioning, namely immediate recall (p=0.001), followed by delayed recall (p=0.001), attention and concentration (p=0.001), recent memory (p=0.001), remote memory (p=0.001), visual retention (p=0.001), retention for similar pairs (p=0.001), mental balance (p=0.001), recognition (p=0.001) as compared to controls. Conclusion: results show that epilepsy does have a significant effect on cognition of children. However, a larger cohort study needs to be carried out to make substantiate claims.
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References
All, W. H. O. (1995). Diagnostic and statistical manual of mental disorders.
Benn, Ek., Hauser, Wa., Shih, T. et al. (2008). Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low-income urban community of Northern Manhattan, New York City. Epilepsia, 49, 1431–9.
Blomberg, O. (2011). Conceptions of Cognition for Cognitive Engineering. The International Journal of Aviation Psychology, 21(1), 85–104.
Chang B.S., Lowenstein D.H. (2003). Epilepsy. New England Journal of Medicine, 349(13), 1257–66.
Elger, C. E., Helmstaedter, C., & Kurthen, M. (2004). Chronic epilepsy and cognition. The Lancet Neurology, 3(11), 663–672.
Epilepsy Foundation. Fact Sheet (2010). Epilepsy Therapy Project. http://www.epilepsyfoundation.org/aboutepilepsy/whatisepilepsy/statistics.cfm
Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R. C., Ritchie, K., Broich, K.,... & Winblad, B. (2006). Mild cognitive impairment. Lancet, 367(9518), 1262–1270.
Greenberg, L. S., Rice, L. N., & Elliott, R. (1996). Facilitating emotional change: The moment-by-moment process. The Guilford Press.
Høie, B., Sommerfelt, K., Waaler, P. E., Alsaker, F. D., Skeidsvoll, H., & Mykletun, A. (2008). The combined burden of cognitive, executive function, and psychosocial problems in children with epilepsy: a population-based study. Developmental Medicine & Child Neurology, 50(7), 530–536.
Hommet, C., Sauerwein, H. C., De Toffol, B., & Lassonde, M. (2006). Idiopathic epileptic syndromes and cognition. Neuroscience & Biobehavioral Reviews, 30(1), 85–96.
Ilae, L. A. E. (2010). Editorial Policies. Epilepsia, 51(9), 1923–1932.
Jackson, HJ. (1981) On temporary mental disorders after epilepsy paroxysms. In Taylor J, ed. Selected Writings of John Hughlings Jackson. Vol 1. London: Hodder and Stonghton: 119–134
Kohli, A. (1998). Measurement of Memory in Children: Construction of a simple clinical tool in Hindi, PGIMER, Chandigarh.
Levin, H. S., Eisenberg, H. M., Wigg, N. R., & Kobayashi, K. (1982). Memory and intellectual ability after head injury in children and adolescents. Neurosurgery, 11(5), 668–673.
Nolan, M. A., Redoblado, M. A., Lah, S., Sabaz, M., Lawson, J. A., Cunningham, A. M.,. & Bye, A. M. (2004). Memory function in childhood epilepsy syndromes. Journal of Paediatrics and Child Health, 40(1-2), 20–27.
Oostrom, K. J., Smeets-Schouten, A., Kruitwagen, C. L., Peters, A. B., & Jennekens-Schinkel, A. (2003). Not only a matter of epilepsy: early problems of cognition and behavior in children with “epilepsy only“—a prospective, longitudinal, controlled study starting at diagnosis. Pediatrics, 112(6), 1338–1344.
Sanyal, S.K., Chandra, P.S., Gupta, S., Tripathi, M., Singh, V.P., Jain, S., Padma, M.V., Mehta, V.S. (2005). Memory and intelligence outcome following surgery for intractable temporal lobe epilepsy: relationship to seizure outcome and evaluation using a customized neuropsychological battery. Epilepsy Behavior 6(2), 147–55.
Seidenberg, M., Pulsipher, D., Hermann, B. (2007). Cognitive progression in epilepsy. Neuropsychology Review, 17, 445–454.
Sternberg, R. J., & Sternberg, K. (2009). Cognitive psychology (6th Ed.). Belmont, CA: Wadsworth, Cengage Learning. U.S. National Library of Medicine. 11 February 2013; http://www.nlm.nih.gov/medlineplus/epilepsy.html
Verma, S.K., Pershad, D. & Kaushal, P. (1972) Gesell Drawing Tests as a measure of intelligence in the mentally retarded children. Indian Journal of Mental Retardation, 5, 64–68.
World Health Organization. Epilepsy Fact sheet No999 October 2012 http://www.who.int/mediacentre/factsheets/fs999/en/
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Nehra, A., Tripathi, M., Bhatia, R. et al. Is Epilepsy a Cause of Cognitive Decline in Developing Brain. Act Nerv Super 55, 112–117 (2013). https://doi.org/10.1007/BF03379601
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DOI: https://doi.org/10.1007/BF03379601