Skip to main content
Log in

(Neuro)biologische Aspekte der Regeneration: Entspannung als Instrument der Stressregulation

Aspects (neuro) biologiques de régénération: la détente comme instrument régulateur de stress

(Neuro)biological aspects of regeneration: Relaxation as a means of stress regulation

  • Published:
Zeitschrift für Arbeitswissenschaft Aims and scope Submit manuscript

Zusammenfassung

Früher war es selbstverständlich, nicht nur im „Wellness-Urlaub“, sondern bereits im Alltag regelmäßige Entspannungs- oder Meditationsrituale - auch zur Regeneration - zu praktizieren. Das war sinnvoll, nicht nur medizinisch, da Entspannung als ein physiologischer und (neuro)biologischer Gegenspieler des Stresses wirken kann. Daher sollten Entspannungsverfahren heute wieder aktiv gelehrt und gelernt werden und in Freizeit, Arbeit und Ausbildung zum Einsatz kommen, insbesondere zur Gesundheitsförderung und Vorbeugung (Prävention).

Résumé

Avant, il était déjà évident que les rituels de relaxation, de méditation et aussi de régénération devaient être pratiqués de manière régulière et pas seulement lors de vacances détente. Cette observation est pleine de bon sens, et ce pas seulement d’un point de vue médical. En effet, la relaxation peut exercer un effet physiologique et (neuro) biologique contre le stress. Aujourd’hui, les procédés de relaxation doivent être à nouveau enseignés et appris. Cette formation doit avoir lieu lors des temps libres (loisirs) et au travail. Elle doit en particulier viser à renforcer la santé et à améliorer la prévention.

Abstract

Over the last 200 years, relaxation and regeneration periods have been expelled from the work environments or daily work routines and delegated to leisure and “recreational” times. This was due, in parts, to modern labor conditions, where productivity and short-term outcome effects determined the organizational structure of labor, and long-term health maintenance or sustainability of the work force became less important: Mobile employees, for example, became increasingly replaceable and workers who spent some time “doing nothing”, while supposedly working, where unproductive, as it seemed-at least in the short run. However, where relaxation was still “allowed”, i.e., outside work, ritualized practices, such as religious procedures (e.g., prayer, churchgoing, or chanting) or regular gatherings with friends or family, including regeneration, slowly disappeared or simply became more difficult to practice due to privacy or separation or the new phenomenon of “consumption and leisure stress”, characterized, e.g., by an excess of social liabilities and opportunities. Consequently, less people used the natural potential of ritualized relaxation or “decelerating” group meetings as an effective means of stress reduction and recovery. As a result, we now putatively experience a steepening increment of (subjective) stress or a diminution of general stress coping capabilities. Accordingly, diseases and stress-associated ailments seem to accumulate almost everywhere. However, stress is a natural phenomenon that is not pathological in itself: It can be examined from different angles and derivations, but we continuously find an astonishing biological stress management potential in each individual, representing, in a sense, a common ground or denominator of our self-healing capabilities, and this physiological potential stems from our ability to auto-/ self-regulate stress and the daily challenges we encounter, including work. Hence, this healthy potential is imbedded in our central nervous system and can be professionally used and trained for better coping and living with stress. Critical ingredients of almost every such stress management concept are formal relaxation techniques. Relaxation techniques, in a scientific sense, are procedures that elicit the so-called “relaxation response”, which is the physiological counter-player of stress or the biological stress response. These techniques are usually easy to learn, quickly rewarding by giving pleasure and “wellness” (mentally and physically), and they can be kept at almost no costs in the daily self-management or self-care regiments. Meanwhile, many studies have proved their effectiveness in a broad array of conditions and stress-associated diseases. From the medical perspective, however, stress management and relaxation techniques seem to be especially useful in the prevention and treatment of cardiovascular risks and illnesses (e.g., hypertension), in addition to some relevant neuro-psychiatric conditions (e.g., depression, anxiety, pain syndromes). Meditation techniques also belong to the repertoire of relaxation response methods. However, to many people the word “meditation” elicits less relaxation but more feelings of discomfort and lack of understanding or even defense. While looking more deeply into the various meditation procedures and their underlying physiology, however, one will find striking parallels and similarities throughout diverse cultures: It almost seems as if the various rituals and techniques, which principally have the potential to elicit the health-promoting relaxation response, as illustrated, have “intentionally” slipped into cultural evolution (independent of the actual region of its origin or emergence or its specific content), not least because of the simple fact that they are healthy. When one tries to scientifically examine the core or common ground of diverse meditation practices, a rather simple meditation instruction turns up, i.e., proto-type. In this way, that is, by scientific reductionism, the Harvard cardiologist Herbert Benson more or less accidentally discovered the relaxation response in the 1970s and, as a consequence, founded the Mind/Body Medical Institute at Harvard Medical School. Moreover, by this means, he also established the new medical field of “mind-body medicine”, which has become increasingly popular over the last 15 years, especially in the United States’ medical community. Today, in Germany too, mind-body medicine is of growing importance in academic medicine, e.g., medical universities and courses, usually in connection with integrative or evidence-based complementary medicine. Yet, it actually is a rather implicit and “non-academic” matter of course: The use, re-discovery, and further development of our inner resources and self-help potentials and the necessity to incorporate this capacity for regeneration and health maintenance into our daily routines (particularly in the midst of a stressful work, leisure and social life) has to become applicable and tangible again-and therefore we simply need to re-train it. Current science is examining the underlying mechanisms and molecular pathways (and even the genetic fit) of the relaxation response: On the receptor level, the autoregulatory molecule nitric oxide and its signaling pathways seem to play a role in the mediation of relaxation’s health-promoting potentials. For example, nitric oxide seems to “desensitize” the organism to stress and reduces a hyper-reactivity against stress hormones by decreasing their molecular impact. In addition, endocannabinoids and just recently detected endogen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  • Adler T.: A complex relationship: Psychosocial stress, pollution, and health. Environmental Health Perspectives 117: A407, 2009

    Article  Google Scholar 

  • Badura, B.; Schröder, H.; Klose, J.; Macco, K.: Fehlzeiten-Report 2009: Arbeit und Psyche: Belastungen reduzieren, Wohlbefinden fördern. Heidelberg, Springer-Verlag, 2009

    Google Scholar 

  • Benson, H.; Beary, J.F.; Carol, M.P.: The relaxation response. Psychiatry 37:37–46, 1974

    Google Scholar 

  • Benson, H.; Stuart, E.M.: The Wellness Book: The Comprehensive Guide to Maintaining Health and Treating Stress-Related Illness. New York, Simon & Schuster, 1993

    Google Scholar 

  • Bilfinger, T.V.; Stefano, G.B.: Human aortocoronary grafts and nitric oxide release: Relationship to pulsatile pressure. Annals of Thoracic Surgery 69: 480–485, 2000

    Article  Google Scholar 

  • Blumenthal, J.A.; Sherwood, A; Babyak, M.A; Watkins, L.L.; Waugh, R.; Georgdiades, A.; Bacon S.L.; Hayano, J.; Coleman, R.E.; Hinderliter, A.: Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: A randomized controlled trial. Journal of the American Medical Association (JAMA) 293: 1626–1634, 2005

    Article  Google Scholar 

  • Cannon, W.: The emergency function of the adrenal medulla in pain and the major emotions. American Journal of Physiology 33: 356–372, 1914

    Google Scholar 

  • Castillo-Richmond, A.; Schneider, R.H.; Alexander, C.N.; Cook, R.; Myers, H.; Nidich, S.; Haney, C.; Rainforth, M.; Salerno, J.: Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans. Stroke 31: 568–573, 2000

    Article  Google Scholar 

  • Chrousos, G.P.; Gold, P.W.: The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. Journal of the American Medical Association (JAMA) 267: 1244–1252, 1992

    Article  Google Scholar 

  • Croft, J.B.; Mokdad, A.H.; Power, A.K.; Greenlund, K.J.; Giles, W.H.: Public health surveillance of serious psychological distress in the United States. International Journal of Public Health 54 (Suppl 1): 4–6, 2009

    Article  Google Scholar 

  • Csikszentmihalyi, M.; Happiness, flow, and economic equality. American Psychologist 55 (10): 1163–1164, 2000

    Article  Google Scholar 

  • Davidson, R.J.; Kabat-Zinn, J.; Schumacher, J.; Rosenkranz, M.; Muller, D.; Santorelli, S.F. et al.: Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine 65: 564–570, 2003

    Article  Google Scholar 

  • Dusek, J.A.; Chang, B.H.; Zaki, J.; Lazar, S.; Deykin, A.; Stefano, G.B.; Wohlhueter, A.L.; Hibberd, P.L.; Benson, H.: Association between oxygen consumption and nitric oxide production during the relaxation response. Medical Science Monitor 12: CR 1–10, 2006

    Google Scholar 

  • Ernst, S.; Esch, S.M.; Esch, T.: (The impact of mindfulness-based interventions on health care.) Forschende Komplementärmedizin 16: 296–303, 2009

    Article  Google Scholar 

  • Esch, T.: Gesund im Stress: Der Wandel des Stresskonzeptes und seine Bedeutung für Prävention, Gesundheit und Lebensstil. Gesundheitswesen 64 (2): 73–81, 2002

    Article  Google Scholar 

  • Esch, T.; Stefano, G.B.: Proinflammation: A common denominator or initiator of different pathophysiological disease processes. Medical Science Monitor 8: HY1–9, 2002

    Google Scholar 

  • Esch, T.; Stefano, G.B.; Fricchione, G.L.; Benson, H.: Stress in cardiovascular diseases. Medical Science Monitor 8: RA93–RA101, 2002

    Google Scholar 

  • Esch, T.: Stress, Anpassung und Selbstorganisation: Gleichgewichtsprozesse sichern Gesundheit und Überleben. Forschende Komplementärmedizin 10 (6): 330–341, 2003

    Article  Google Scholar 

  • Esch, T.; Stefano, G.B.; Fricchione, G.L.: The therapeutic use of the relaxation response in stress-related diseases. Medical Science Monitor 9: RA23–34, 2003

    Google Scholar 

  • Esch, T.; Stefano, G.B.: The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinology Letters 25: 235–251, 2004

    Google Scholar 

  • Esch, T.; Guarna, M.; Bianchi, E.; Zhu, W.; Stefano, G.B.: Commonalities in the central nervous system’s involvement with complementary medical therapies: Limbic morphinergic processes. Medical Science Monitor 10: MS6–MS17, 2004

    Google Scholar 

  • Esch, T.; Michalsen, A.; Stefano, G.B.: Endocannabinoide als molekulare Instrumente der Gesundheitsförderung. Medizinische Monatsschrift für Pharmazeuten 29 (11): 397–403, 2006

    Google Scholar 

  • Esch, T.; Stefano, G.B.: A bio-psychosocio-molecular approach to pain and stress management. Forschende Komplementärmedizin 14: 224–234, 2007

    Article  Google Scholar 

  • Esch, T.; Mind-Body-Medizin: Stress, Stressmanagement und Gesundheitsförderung. Komplementäre und Integrative Medizin 49: 35–39, 2008

    Article  Google Scholar 

  • Esch, T.; Stefano, G.B.: The neurobiology of stress management. Neuroendocrinology Letters 31 (1): 19–39, 2010

    Google Scholar 

  • Esch, T.: Von der Kuration zur Gesundheitsförderung — Paradigmenwechsel in der ärztlkichen Beratung. In: Heintze C (Hrsg). Adipositas und Public Health. München, Juventa, 2010

    Google Scholar 

  • Fritz, S.; Richter, P.: Effektivität und Nutzen betrieblicher Gesundheitsförderung — Wie lässt sich beides sinnvoll messen? Prävention und Gesundheitsförderung 12: 1–7, 2010

    Google Scholar 

  • Goetzel, R.Z.; Ozminkowski, R.J.: The health and cost benefits of work site healthpromotion programs. Annual Review of Public Health 29: 303–323, 2008

    Article  Google Scholar 

  • Goldgruber, J.; Ahrens, D.: Gesundheitsbezogene Interventionen in der Arbeitswelt. Prävention und Gesundheitsförderung 1: 83–95, 2009

    Article  Google Scholar 

  • Gottholmseder, G.; Nowotny, K.; Pruckner, G.J.; Theurl, E.: Stress perception and commuting. Health Econ 18: 559–576, 2009

    Article  Google Scholar 

  • Hoffman, J.W.; Benson, H.; Arns, P.A. et al:. Reduced sympathetic nervous system responsivity associated with the relaxation response. Science 215: 190–192, 1982

    Article  Google Scholar 

  • Hollederer, A.: Betriebliche Gesundheitsförderung in Deutschland-Ergebnisse des IAB-Betriebspanels 2002 und 2004. Gesundheitswesen 69: 63–76, 2007

    Article  Google Scholar 

  • Jones, F.; Bright, J.; Clow, A.: Stress. Myth, Theory and Research. New York, Prentice Hall, 2001

    Google Scholar 

  • Khalsa, D.S.; Amen, D.; Hanks, C.; Money, N.: Newberg A. Cerebral blood flow changes during chanting meditation. Nucl Med Commun 30: 956–961, 2009

    Article  Google Scholar 

  • Kivimäki, M.; Leino-Arjas, P.; Luukonen, R.; Riihimaki, H.; Vahtera, J.; Kirjonen, J.: Work stress and risk of cardiovascular mortality: Prospective cohort study of industrial employees. British Medical Journal 325: 857, 2002

    Article  Google Scholar 

  • Komaroff, A.L.: Mind-Body Medicine: A Special Health Report. Boston, Harvard Health Publications, 2001

    Google Scholar 

  • Krantz, D.S.; Kop, W.J.; Santiago, H.T.; Gottdiener, J.S.: Mental stress as a trigger of myocardial ischemia and infarction. Cardiol Clin 14: 271–287, 1996

    Article  Google Scholar 

  • Kuper, H.; Singh-Manoux, A.; Siegrist, J.; Marmot, M.: When reciprocity fails: Effort-reward imbalance in relation to coronary heart disease and health functioning within the Whitehall II study. Occupational and Environmental Medicine 59: 777–784, 2002

    Article  Google Scholar 

  • Lazar, S.W.; Bush, G.; Gollub, R.L.; Fricchione, G.L.; Khalsa, G.; Benson, H.: Functional brain mapping of the relaxation response and meditation. Neuroreport 11: 1581–1585, 2000

    Article  Google Scholar 

  • Lazar, S.W.; Kerr, C.E.; Wasserman, R.H.; Gray, J.R.; Greve, D.N.; Treadway, M.T.; McGarvey, M.; Quinn, B.T.; Dusek, J.A.; Benson, H.; Rauch, S.L.; Moore, C.I.; Fischl, B.: Meditation experience is associated with increased cortical thickness. Neuroreport 16: 1893–1897, 2005

    Article  Google Scholar 

  • Linden, W.; Lenz, J.W.; Con, A.H.: Individualized stress management for primary hypertension: A randomized trial. Archives of Internal Medicine 161: 1071–1080, 2001

    Article  Google Scholar 

  • Liu, Y.; Shenouda, D.; Bilfinger, T.V.; Stefano, M.L.; Magazine, H.I.; Stefano, G.B.: Morphine stimulates nitric oxide release from invertebrate microglia. Brain Research 722: 125–131, 1996

    Article  Google Scholar 

  • Magazine, H.I.; Liu, Y.; Bilfinger, T.V. et al.: Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. Journal of Immunology 156: 4845–4850, 1996

    Google Scholar 

  • Mantione, K.J.; Esch, T.; Stefano, G.B.: Detection of nitric oxide in exhaled human breath: Exercise and resting determinations. Medical Science Monitor 13: MT1–5, 2007

    Google Scholar 

  • Mantione, K.J.; Cadet, P.; Zhu W.; Kream, R.M.; Sheehan, M.; Fricchione, G.L.; Goumon, Y.; Esch, T.; Stefano, G.B.: Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addiction Biology 13: 118–123, 2008

    Article  Google Scholar 

  • Mantione, K.J.; Zhu, W.; Kream, R.M.; Esch, T.; Stefano, G.: Regulation of the transcription of the Catechol-O-Methyltransferase Gene by morphine and epinephrine. Activitas Nervosa Superior Rediviva 52 (1): 51–56, 2010

    Google Scholar 

  • McEwen, B.S.: Protective and damaging effects of stress mediators. New England Journal of Medicine 338: 171–179, 1998

    Article  Google Scholar 

  • McEwen, B.S.: The brain is the central organ of stress and adaptation. Neuroimage 47: 911–913, 2009

    Article  Google Scholar 

  • Metz, U.; Welke, J.; Esch, T.; Renneberg, B.; Braun, V.; Heintze, C.: Perception of Stress and Quality of life in overweight and obese people-Implications for preventive consultancies in primary care. Medical Science Monitor 15: PH1–6, 2009

    Google Scholar 

  • Michalsen, A.; Grossman, P.; Acil, A.; Langhorst, J.; Luedtke, R.; Esch, T.; Stefano, G.B.; Dobos, G.J.: Rapid stress reduction and anxiolysis among distressed women as a consequence of a three-month intensive yoga program. Medical Science Monitor 11: CR555–561, 2005

    Google Scholar 

  • Newberg, A.; Alavi, A.; Baime, M.; Pourdehnad, M.; Santanna, J.; d’Aquili, E.: The measurement of regional cerebral blood flow during the complex cognitive task of meditation: A preliminary SPECT study. Psychiatry Research 106: 113–122, 2001

    Article  Google Scholar 

  • Ornish, D.; Scherwitz, L.W.; Billings, J.H.; Brown, S.E.; Gould, K.L.; Merritt, T.A.; Sparler, S.; Armstrong, W.T.; Ports, T.A.; Kirkeeide, R.L. et al:. Intensive lifestyle changes for reversal of coronary heart disease. Journal of the American Medical Association (JAMA) 280: 2001–2007, 1998

    Article  Google Scholar 

  • Ospina, M.B.; Bond, T.K.; Karkhaneh, M. et al.: Meditation Practices for Health: State of the Research. Evidence Report/Technology Assessment No. 155. AHRQ Publication, Rockville, Agency for Healthcare Research and Quality, 2007

    Google Scholar 

  • Patel, C.: Stress management and hypertension. Acta Physiol Scand Suppl 640: 155–157, 1997

    Google Scholar 

  • Rosengren, A.; Hawken, S.; Ounpuu, S. et al.: Association of psychosocial risk factors with risk of acute myocardial infarction in 11.119 cases and 13.648 controls from 52 countries. Lancet 364: 953–962, 2004

    Article  Google Scholar 

  • Rossano, M.J.: Did meditating make us human? Cambridge Archaeological Journal 17: 47–58, 2007

    Article  Google Scholar 

  • Roustit, C.; Chaix, B.; Chauvin, P.: Family breakup and adolescents’ psychosocial maladjustment: Public health implications for family disruptions. Pediatrics 120: e984–991, 2007

    Article  Google Scholar 

  • Salamon, E.; Esch, T.; Stefano, G.B.: Pain and relaxation. International Journal of Molecular Medicine 18: 465–470, 2006

    Google Scholar 

  • Schwartz, G.E.: Stress management in occupational settings. Public Health Report 95: 99–108, 1980

    Google Scholar 

  • Selye, H.: The Physiology and Pathology of Exposure to Stress. Montreal, Acta Inc. Medical Publishers, 1950

    Google Scholar 

  • Siegrist, J.: Verletzte soziale Reziprozität macht krank: Ein medizinsoziologisches Forschungsmodell. Forschende Komplementärmedizin 9: 31–36, 2002

    Article  Google Scholar 

  • Stauder, A.; Konkoly Thege B.; Kovacs, M.E.; Balog, P.; Williams, V.P.; Williams, R.B.: Worldwide stress: Different problems, similar solutions? Cultural adaptation and evaluation of a standardized stress management program in Hungary. International Journal of Behavioral Medicine, 2009

    Google Scholar 

  • Stefano, G.B.; Hartman, A.; Bilfinger, T.V. et al.: Presence of the mu3 opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilation. J Biol Chem 270: 30290–30293, 1995

    Article  Google Scholar 

  • Stefano, G.B.; Goumon, Y.; Bilfinger, T.V. et al.: Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Progress in Neurobiology 60: 531–544, 2000

    Article  Google Scholar 

  • Stefano, G.B.; Fricchione, G.L.; Slingsby, B.T.; Benson, H.: The placebo effect and relaxation response: Neural processes and their coupling to constitutive nitric oxide. Brain Research: Brain Research Reviews 35: 1–19, 2001a

    Article  Google Scholar 

  • Stefano, G.B.; Murga, J.; Benson, H.; Zhu, W.; Bilfinger, T.V.; Magazine, H.I.: Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta. Pharmacology Research 43: 199–203, 2001b

    Article  Google Scholar 

  • Stefano, G.B.: Biomedical significance of nitric oxide. New York, Medical Science International, 2003

    Google Scholar 

  • Stefano, G.B.; Zhu, W.; Cadet, P.; Mantione, K.: Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the mu3 opiate receptor subtype: A hormonal role for endogenous morphine. J Physiol Pharmacol 55: 279–288, 2004

    Google Scholar 

  • Stefano, G.B.; Benson, H.; Fricchione, G.L.; Esch, T.: The Stress Response: Always Good and When It Is Bad. New York, Medical Science International, 2005

    Google Scholar 

  • Stefano, G.B.; Esch, T.: Integrative medical therapy: Examination of meditation’s therapeutic and global medicinal outcomes via nitric oxide. International Journal of Molecular Medicine 16: 621–630, 2005

    Google Scholar 

  • Stefano, G.B.; Fricchione, G.L.; Esch, T.: Relaxation: Molecular and physiological significance. Medical Science Monitor 12: HY21–31, 2006

    Google Scholar 

  • Stefano, G.B.; Stefano, J.M.; Esch, T.: Anticipatory Stress Response: A significant commonality in stress, relaxation, pleasure and love responses. Medical Science Monitor 14: RA17–21, 2008

    Google Scholar 

  • Van Dixhoorn, J.; Duivenvoorden, H.J.; Pool, J.; Verhage, F.: Psychic effects of physical training and relaxation therapy after myocardial infarction. Journal of Psychosomatic Research 34: 327–337, 1990

    Article  Google Scholar 

  • Zhu, W.; Mantione, K.J.; Shen, L.; Cadet, P.; Esch, T.; Goumon, Y.; Bianchi, E.; Sonetti, D.; Stefano, G.B.: Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Medical Science Monitor 11 (11): BR397–404, 2005

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tobias Esch.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Esch, T. (Neuro)biologische Aspekte der Regeneration: Entspannung als Instrument der Stressregulation. Z. Arb. Wiss. 65, 125–135 (2011). https://doi.org/10.1007/BF03373826

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03373826

Schlüsselwörter

Mots clés

Keyword

Navigation