Skip to main content
SpringerLink
Log in

Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent

  • Brief Report
  • Published:
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

The G-protein ß3 subunit 825 TT genotype has been associated with obesity and hypertension. We examined the interaction between the G-protein TT genotype, physical activity and body mass index (BMI) in a cross-sectional study of African immigrants and African Americans. The genotype frequencies were 6.3% CC, 37.7% CT, and 56% TT. After adjusting for potential confounders, BMI was found to be significantly higher in the sedentary than in the physically active participants (p=0.045). There was no statistically significant effect for genotype (p=0.215) or the interaction between genotype and the level of physical activity (p=0.219). However, the individuals with the CC or CT genotype who were physically active had substantially lower BMIs (M±SE) (i.e., 25.74±2.02) than any of the other groups: sedentary CC + CT (30.58±1.03), sedentary TT (30.65±1.00) or active TT (29.43±1.65). Because of the low statistical power of this study, further research is needed to confirm these findings and to explore potential gene-environment/lifestyle interactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Comuzzie A.G., Allison D.B.: The search for human obesity genes. Science, 280, 1374–1377, 1998.

    Article  CAS  PubMed  Google Scholar 

  2. Siffert W., Forster P., Jöckel K.H., et al.: Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol., 10, 1921–1930, 1999.

    CAS  PubMed  Google Scholar 

  3. Siffert W., Naber C., Walla M., Ritz E.: G protein beta3 subunit 825T allele and its potential association with obesity in hypertensive individuals. J. Hypertens., 17, 1095–1098, 1999.

    Article  CAS  PubMed  Google Scholar 

  4. Hegele R.A., Anderson C., Young T.K., Connelly P.W.: G-protein b3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res., 9, 972–977, 1999.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Gutersohn A., Naber C., Müller N., Erbel R., Siffert W.: G protein beta3 subunit 825 TT genotype and post-pregnancy weight retention. Lancet, 355, 1240–1241, 2000.

    Article  CAS  PubMed  Google Scholar 

  6. Siffert W., Roskopf D., Erbel R.: Genetic polymorphisms of the G-protein beta3 subunit, obesity, and essential hypertension. Herz, 25, 26–33, 2000.

    Article  CAS  PubMed  Google Scholar 

  7. Poston W.S.C., Pavlik V.N., Hyman D.J., et al.: Genetic bottlenecks, perceived racism, and hypertension risk among African Americans and first generation African immigrants. J. Hum. Hypertens, 2001, 15, 341–351.

    Article  CAS  PubMed  Google Scholar 

  8. Miller S.A., Dykes D.D., Polesky H.F.: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res., 16, 1212, 1988.

    Article  Google Scholar 

  9. Benjafield A.V., Jeyasingam C.L., Nyholt D.R., Griffiths L.R., Morris B.J.: G-protein beta 3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension, 32, 1094–1097, 1998.

    Article  CAS  PubMed  Google Scholar 

  10. National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI): Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity: The evidence report. Washington D.C. Washington DC, US Government Press, 1998.

    Google Scholar 

  11. Jackson A.S., Wier L.T., Ross R.M.: The validity of non-exercise cardiorespiratory fitness prediction models. Med. Sci. Sports Exerc., 27, 1096–1098, 1995.

    Article  CAS  PubMed  Google Scholar 

  12. Jackson A.S., Blair S.N., Mahar M.T., Wier L.T., Ross R.M., Stuteville J.E.: Prediction of functional aerobic capacity without exercise testing. Med. Sci. Sports Exerc., 22, 863–870, 1990.

    Article  CAS  PubMed  Google Scholar 

  13. Jackson A.S., Beard E.F., Wier L.T., Ross R.M., Stuteville J.E., Blair S.N.: Changes in aerobic power of men, ages 25–70 yr. Med. Sci. Sports Exerc., 27, 113–120, 1995.

    CAS  PubMed  Google Scholar 

  14. Jackson A.S., Wier L.T., Ayers G.W., Beard E.F., Stuteville J.E., Blair S.N.: Changes in aerobic power of women, ages 20–64 yr. Med. Sci. Sports Exerc., 28, 884–891, 1996.

    Article  CAS  PubMed  Google Scholar 

  15. Arday D.R., Tomar S.L., Nelson D.E., Merritt R.K., Schooley M.W., Mowery P.: State smoking prevalence estimates: A comparison of the Behavioral Risk Factor Surveillance System and current population surveys. Am. J. Public Health, 87, 1665–1669, 1997.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. National Center for Health Statistics (NCHS): Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–1994. Vital Health Stat. 1 (32) (DHHS publication no. [PHS] 94-1308). Hyattsville, MD, U.S. Department of Health and Human Services, 1994.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mid America Heart Institute and the University of Missouri-Kansas City, USA

    Walker S. Carlos Poston M.P.H., Ph.D., C.K. Haddock, J. Spertus & D.M. Catanese

  2. Department of Family and Community Medicine, Baylor College of Medicine, USA

    V.N. Pavlik

  3. Department of Medicine, Baylor College of Medicine, USA

    D.J. Hyman & J.P. Foreyt

  4. Human Genetics Center, University of Texas Houston Health Science Center, USA

    C.L. Hanis

Authors
  1. Walker S. Carlos Poston M.P.H., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C.K. Haddock
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Spertus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D.M. Catanese
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V.N. Pavlik
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D.J. Hyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C.L. Hanis
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J.P. Foreyt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Walker S. Carlos Poston M.P.H., Ph.D..

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Poston, W.S.C., Haddock, C., Spertus, J. et al. Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent. Eat Weight Disord 7, 68–71 (2002). https://doi.org/10.1007/BF03354432

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03354432

Key words

Search

Navigation