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Zinc supplementation in the treatment of anorexia nervosa

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript


The clinical manifestations of zinc deficiency and anorexia nervosa are remarkably similar, and a number of studies have demonstrated that there may be a positive correlation between zinc therapy and the rate of recovery of anorexia nervosa patients. However, because of the different interpretations of the results of these studies, the use of zinc supplementation varies. This article examines the evidence supporting zinc supplementation in the treatment of anorexia nervosa. Randomised, double-blind, controlled clinical trials indicate that zinc therapy enhances the rate of recovery in anorexia nervosa patients by increasing weight gain and improving their levels of anxiety and depression. On the basis of these findings and the low toxicity of zinc, zinc supplementation should be included in the treatment protocol for anorexia nervosa.

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  1. Bakan R.: The role of zinc in anorexia nervosa: etiology and treatment. Med. Hypotheses, 5, 731–736, 1979.

    Article  CAS  PubMed  Google Scholar 

  2. Esca S.A., Brenner W., Mach K., Gschnait F.: Kwashiorkor-like zinc deficiency syndrome in anorexia nervosa. Acta Dermatol. Venereol. (Stockh.), 59, 361–364, 1979.

    CAS  Google Scholar 

  3. Bryce-Smith D., Simpson R.I.D.: Case of anorexia nervosa responding to zinc sulphate. Lancet, 2, 350, 1984.

    Article  CAS  PubMed  Google Scholar 

  4. Safai-Kutti S., Kutti J.: Zinc and anorexia nervosa. Ann. Intern. Med., 100, 317–318, 1984.

    Article  CAS  PubMed  Google Scholar 

  5. Safai-Kutti S., Kutti J.: Zinc therapy in anorexia nervosa. Am. J. Psychiatry, 143, 1059, 1986.

    CAS  PubMed  Google Scholar 

  6. Humphries L.L., Vivian B., Stuart M., McClain C.J.: Zinc deficiency and eating disorders. J. Clin. Psychiatry, 50, 456–459, 1989.

    CAS  PubMed  Google Scholar 

  7. Safai-Kutti S.: Oral zinc supplementation in anorexia nervosa. Acta Psychiatr. Scand. Suppl., 361, 14–17, 1990.

    Article  CAS  PubMed  Google Scholar 

  8. Katz R.L., Keen C.L., Litt I.F., Hurley L.S., Kellams-Harrison K.M., Glader L.J.: Zinc deficiency in anorexia nervosa. J. Adolesc. Health Care, 8, 400–406, 1987.

    Article  CAS  PubMed  Google Scholar 

  9. McClain C.J., Stuart M., Vivian B., McClain M., Talwalker R., Snelling L., Humphries L.: Zinc status before and after zinc supplementation of eating disorder patients. J. Am. Coll. Nutr., 11, 694–700, 1992.

    Article  CAS  PubMed  Google Scholar 

  10. Birmingham C.L., Goldner E.M.: Eating disorders. In: Gray J. (Ed.), Therapeutic choices, 2nd ed., Canada, Canada Pharmaceutical Association, 1998, pp. 38–45.

    Google Scholar 

  11. Canadian Task Force on the Periodic Health Examination, The Canadian Guide to Clinical Preventive Health Care. Ottawa, Minister of Supply and Services Canada, 1994.

    Google Scholar 

  12. Birmingham C.L., Goldner E.M., Bakan R.: Controlled trial of zinc supplementation in anorexia nervosa. Int. J. Eat. Disord., 15, 251–255, 1994.

    CAS  PubMed  Google Scholar 

  13. Lask B., Fosson A., Rolfe U., Thomas S.: Zinc deficiency and childhood-onset anorexia nervosa. J. Clin. Psychiatry, 54, 63–66, 1993.

    CAS  PubMed  Google Scholar 

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Correspondence to C.L. Birmingham.

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Su, J., Birmingham, C. Zinc supplementation in the treatment of anorexia nervosa. Eat Weight Disord 7, 20–22 (2002).

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