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Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system

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Abstract

Continuous light (CL) induces constant estrous anovulatory (CEA) syndrome and blockade of pineal gland activity. Chronic treatment with melatonin is able to overcome the anovulatory state in about 70% of CL-CEA rats, and the luteinizing effect of melatonin is significantly counteracted either by feeding the animals with a tryptophan-poor diet or by injecting methiothepin, a blocker of central serotoninergic receptors. It appears that melatonin elicits luteinization in CL-CEA rats through the brain serotoninergic system.

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Authors and Affiliations

  1. Department of Pathological Anatomy, University of Modena, Via Berengario, 4, 41100, Modena, Italy

    G. P. Trentini & C. F. De Gaetani

  2. Department of Anatomy, University Medical School, Pécs, Hungary

    B. Mess & C. Ruzsás

Authors
  1. G. P. Trentini
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  2. B. Mess
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  3. C. F. De Gaetani
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  4. C. Ruzsás
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Trentini, G.P., Mess, B., De Gaetani, C.F. et al. Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system. J Endocrinol Invest 1, 305–310 (1978). https://doi.org/10.1007/BF03350974

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